The change in motor symptoms after deep brain stimulation (DBS) in people with Parkinson’s disease did not differ regardless of whether microelectrode recording was used during their surgery to guide electrode placement, a pooled analysis of published studies suggest. However, the analysis found that a reduction in the…
Nanomaterials with potent antioxidant properties called carbon quantum dots prevented Parkinson’s disease-related neurodegeneration in nerve cells and a worm model, a study reported. These antioxidants, especially those derived from citric acid — a common and nontoxic biochemical — may represent a new treatment approach for Parkinson’s and other neurodegenerative diseases,…
People with Parkinson’s disease reported enjoying and benefiting physically and emotionally from a community cycling program — Pedaling for Parkinson’s (PFP) — viewing it favorably in a survey regardless of their age or disease symptoms and severity, a study of patients at five PFP sites reported. The aerobic program’s cost, access…
Koneksa has been awarded a grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to investigate the potential of digital biomarkers to evaluate and predict disease progression in people with Parkinson’s disease. Digital biomarkers have the potential to aid in diagnosing Parkinson’s and allowing patients…
Treatment with prasinezumab, a monoclonal antibody designed to break up toxic alpha-synuclein aggregates, failed to slow the progression of Parkinson’s disease in a Phase 2 clinical trial. “In this placebo-controlled trial, treatment with prasinezumab, a humanized monoclonal antibody targeting aggregated [alpha]-synuclein, had no meaningful effect on global clinical or…
Physical activity may be beneficial to brain health, including for people with neurodegenerative diseases such as Parkinson’s disease, by promoting increases in brain volume, a long-term follow-up study suggests. “Our study results indicate that even small behavioral changes, such as walking 15 minutes a day or taking the stairs…
Fluctuations in weight, either a loss or a gain, occurred significantly more often in people with Parkinson’s disease than in those without the progressive neurodegenerative disorder, a study has found. Weight loss in Parkinson’s patients was associated with a faster progression of motor and cognitive declines over a five-year…
A miniature antibody-like molecule called a nanobody effectively broke up toxic alpha-synuclein aggregates that are characteristic of Parkinson’s disease, and prevented the spread of these aggregates in the brains of mice in a disease model. The novel construct was described in the journal Nature Communications, in the study, “…
Treatment with Kynmobi (apomorphine hydrochloride), an approved under-the-tongue therapy for “off” episodes in Parkinson’s disease, does not substantially alter heartbeat dynamics at approved doses, according to new clinical trial data. The study, “A Randomized Thorough QT Study of Apomorphine Sublingual Film in Patients With Parkinson’s…
Researchers have developed a new method of temporarily opening the selective blood-brain barrier (BBB) to allow therapeutic molecules greater access to the brain. Difficulties in developing molecules that can cross this barrier have long hindered the development of treatments for neurological diseases, like Parkinson’s disease. The technique could now…
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