Author Archives: Marisa Wexler

Small Molecules, STARs Treat Cell Models of GBA1-linked Parkinson’s

Two investigational small molecules known as GT-02287 and GT-02329 lowered toxic protein levels in patient-derived cell models of Parkinson’s disease associated with a mutation in GBA1, their developer, Gain Therapeutics, announced. Gain is planning additional preclinical studies this year that could support applications to regulatory agencies allowing the compounds to…

Variety of Ways to Help Patients With Walking Not Widely Known

People with gait difficulties due to Parkinson’s disease make adjustments that aid in walking, but many are not aware of the variety of “compensation strategies” available to them, a study based on a patient survey reported. Some of these strategies may be more useful in certain situations or to a given…

B-SOiD Algorithm May Make it Easier to Study Behavior

A novel machine learning algorithm called B-SOiD quickly and efficiently analyzes animal behaviors, and may be useful in assessing movement disorders in people with Parkinson’s disease. Researchers described their findings in the study, “B-SOiD, an open-source unsupervised algorithm for identification and fast prediction of behaviors,” published in Nature…

Many Patients Harbor Misconceptions About Vaccines

Many people with Parkinson’s disease have misconceptions about routine vaccinations, with more than one of 10 patients thinking they are not recommended for people with Parkinson’s — even though they very much are, as they can be life-saving. The results, based on a survey of patients in the U.S.,…

Uric Acid May Help to Protect Neurons, Ease Non-motor Symptoms

Among people with Parkinson’s disease, those with low blood levels of uric acid — a natural antioxidant — tend to have more severe non-motor symptoms like anxiety, depression, and cognitive dysfunction, a study indicates. It also showed a link between uric acid levels and gray matter volume in the…

Electrical Stimulation of Brain via Scalp May Ease Bradykinesia

Electrical stimulation given through the scalp to a brain region called the supplementary motor area may ease certain aspects of upper limb bradykinesia in people with Parkinson’s disease, a small study suggests. The study, “Transcranial direct current stimulation of supplementary motor area improves upper limb kinematics…

Clinical Trials of Parkinson’s Therapies Robust Despite COVID-19

Despite the impact of the COVID-19 pandemic, investment and interest in clinical trials of potential new treatments for Parkinson’s disease remains strong, according to a report. The study suggests that the landscape of developmental Parkinson’s treatments has changed little over the last year, with researchers noting a slight increase…

Low-frequency DBS May Help Parkinson’s Patients With Walking

Low-frequency deep brain stimulation (DBS) may help to ease balance problems due to postural instability in people with Parkinson’s disease, a small clinical trial reported. But patients with significant tremor prior to starting DBS may not find the treatment tolerable, because it can lead to the re-emergence of…

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