Author Archives: Marisa Wexler

Mitochondrial Dysfunction Enough to Cause Parkinson’s in Mice

Mitochondrial dysfunction in dopamine-producing brain cells is sufficient to cause Parkinson’s disease, according to a new study done in mice. The study, “Disruption of mitochondrial complex I induces progressive parkinsonism,” was published in Nature. Parkinson’s is caused by the death and dysfunction of dopamine-producing (dopaminergic) neurons.

CST-103 Improves Brain Blood Flow in Early Clinical Trial

Treatment with the investigational therapy CST-103 increased blood flow to certain regions of the brains of people with Parkinson’s disease and mild cognitive impairment, results of a small clinical trial show. The type of increased blood flow that was seen “correlates with increased neuronal activity and cognitive benefit,” Gabriel…

Longer ‘On’ Time Seen With Infused ABBV-951 Than Oral Levodopa in Trial

ABBV-951, an under-the-skin formulation of levodopa/carbidopa, outperformed the standard oral therapy at controlling Parkinson’s symptoms in advanced disease patients in a Phase 3 clinical trial, top-line results show. “These data are promising and demonstrate positive results on a key endpoint used to assess efficacy of treatments for patients with…

Studies Into How Alpha-synuclein Affects Key Immune Cell Needed

More research is needed to understand how alpha-synuclein — a protein whose accumulation is characteristic of Parkinson’s disease — affects cells other than nerve cells, particularly microglia, the resident immune cell of the brain. A pair of researchers at the Van Andel Institute in Michigan raised this argument after…

Low Levels of Vitamin B6 and B12 Linked to Patients’ Nerve Damage

Neuropathy, or nerve damage, was linked to abnormally low levels of the vitamins B6 and B12 in three people with Parkinson’s disease, according to a case report. “All patients were consecutively identified within one year at a single institution,” the researchers wrote, which suggests that neuropathy associated with low levels…

Reduced Dopamine Shown to Impact Activity in Brain Motor Cortex

Reduced dopamine signaling leads to abnormal activity in the motor cortex— the part of the brain chiefly responsible for controlling movement — a new study in mice illustrates. This result helps to shed light on the biological underpinnings of Parkinson’s disease, which is characterized by abnormally low dopamine levels…

Study: Nearly 40% of Patients Have Minor Hallucinations

Nearly four of every 10 patients with Parkinson’s disease experience minor hallucinations, a new study from China estimates. Results suggest a link between minor hallucinations and Parkinson’s-related sleep problems. The study, “Prevalence and Risk Factors for Minor Hallucinations in Patients with Parkinson’s Disease,” was published in …

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