Eight weeks of leg strength training failed to prevent sudden drops in blood pressure upon standing, a condition called orthostatic hypotension, in people with Parkinson’s disease, according to a small pilot study. “Further controlled clinical trials with larger sample sizes and sufficient power are required to investigate the effect…

Parkinson’s is a progressive illness. It’s continually changing the brain and body as we grow older. Along with changes from my Parkinson’s, my brain is also changing in response to its “owner’s” demands. I’ve proposed that it’s possible to use this natural neuroplasticity to slow the progression of…

A protein called TMEM175 is critically important for maintaining the proper acidity of lysosomes — cellular compartments that clear waste — and its deficiency led to the buildup of the toxic protein alpha-synuclein in the brains of mice. That finding from a recent study may underlie the previously identified link…

Scientists in Germany have developed the first highly sensitive test to detect altered alpha-synuclein proteins in blood samples from patients with Parkinson’s disease. The test accurately distinguishes people with Parkinson’s from those without the disease and has the potential to detect the disease early, before symptoms start, according to…

Overactivation of microglia cells — known to drive neuroinflammation in diseases like Parkinson’s — can be detected by measuring a panel of different proteins in the cerebrospinal fluid (CSF), the liquid that surrounds the brain and spinal cord, a study reports. The finding supports the potential of these proteins as…