Copper supplementation that reaches the brain reduces the signs and symptoms of Parkinson’s disease in a mouse model, a study found. Researchers found that copper restored the function of SOD1, an antioxidant enzyme that’s prone to misfolding and forming toxic clumps, impairing the function of dopamine-producing nerve cells that…
Changes in the bacterial communities in the gut and mouth are associated with cognitive impairment in people with Parkinson’s disease, a study suggests. Some oral bacteria and related virulence factors, such as molecules that help bacteria colonize the body — many of which can trigger a potent inflammatory response…
Casma Therapeutics said it will develop CSM-101 as a potential disease-modifying oral treatment for people with Parkinson’s disease and Gaucher disease. CSM-101 is a first-in-class small molecule designed to activate the calcium channel TRPML1, a key regulator of lysosomal function and autophagy, a process in which cells deliver…
People in the presymptomatic stages of Parkinson’s disease have distinct patterns of stimulated immune responses relative to those with clinically diagnosed disease or individuals who do not have Parkinson’s, according to a new study. In particular, the release of certain immune signaling proteins from isolated and stimulated immune cells…
Switching actions and stopping movements involve two distinct cognitive motor processes, according to a study that combined computer modeling with tasks performed by healthy people. The findings have implications for people with Parkinson’s disease, who experience longer reaction times and delays when they want to start, stop, or switch…
A newly developed test was able to distinguish — with an accuracy of 95% — between individuals with and without Parkinson’s disease, using samples of cerebrospinal fluid (CSF), the liquid surrounding the brain and spinal cord, according to a new study from Germany. The researchers noted that Parkinson’s often…
Different types of exercise can have different effects on Parkinson’s disease, a study suggests. For instance, tai chi or at-home bodyweight strength training can improve motor function, while tai chi or strength training with elastic bands and dumbbells can help ease freezing of gait. At the same time, home-based…
Adults with Parkinson’s disease treated with the cell therapy bemdaneprocel spent less time in off periods, when symptoms were not adequately controlled despite medication use. That’s according to final published data from the exPDite Phase 1 trial (NCT04802733), which also showed that the cell therapy boosted the time…
Performing cognitive tasks while walking may help distinguish between early Parkinson’s disease and multiple system atrophy (MSA), a neurodegenerative disorder with similar symptoms, a study suggests. MSA patients had more walking impairments alongside higher brain activity during cognitive tasks while walking than Parkinson’s patients, the research shows. “We…
Age-related declines in speech processes do not appear to contribute to the voice disturbances perceived by people with Parkinson’s disease, and are more likely due to disease processes themselves, a study reports. “Reduced self-voice perception in [Parkinson’s] is likely due to [Parkinson’s]-specific sensory feedback deficits, rather than age per…
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