People with Parkinson’s disease who experience digestive issues or probable rapid eye movement (REM) sleep behavior disorder may be as much as twice as likely to develop symptoms of psychosis, a study found. Understanding what predicts early-onset psychosis in Parkinson’s can help doctors identify at-risk patients sooner, enabling them…

People with REM sleep behavior disorder, a condition that often precedes Parkinson’s disease, frequently have mitochondrial DNA (mtDNA) damage, a study found. “Patients with REM sleep behavior disorder, both those who subsequently developed Parkinson’s disease and those who did not, had more mitochondrial DNA circulating in the cerebrospinal fluid…

Patterns of brain damage in Parkinson’s disease differ based on whether or not individuals have REM sleep behavior disorder (RBD), a new study suggests. Study findings indicate that patterns of brain damage are similar among Parkinson’s patients who develop RBD before or after Parkinson’s motor symptoms. Based on…

Treatment with CST-103, CuraSen Therapeutics’ investigational oral molecule, safely led to cognitive improvements in people with Parkinson’s disease or mild cognitive impairment (MCI), according to top-line data from a Phase 2 clinical trial. By combining the CST-103, which is able to enter the brain, with a molecule…

As I close my eyes, my body gears up for the night’s adventures, which begin to appear in a whirlwind of color. Buildings tower above me, reflecting the warm sun in the sky. I see people walking in and out of them. I feel as if I am actually in…

Blood levels of c-reactive protein (CRP) and the lymphocyte-to-monocyte ratio (LMR), two indicators of systemic inflammation, were associated with the presence of rapid eye movement (REM) sleep behavior disorder (RBD) in people with Parkinson’s disease, a study found. Patients with RBD also had worse cognition than those who did…

People with Parkinson’s disease and rapid eye movement (REM) sleep behavior disorder — marked by acting out dreams, sometimes violently — showed no significant differences in their levels of tumor necrosis factor (TNF)-alpha, an inflammatory protein, and orexin, a protective protein, relative to patients without this sleep disorder or people…

Over the years, I have visited with many neurologists across multiple states regarding my Parkinson’s disease (PD). In their clinical interviews, they ask if I’m thrashing in my sleep. Then, they ask Mrs. Dr. C. It seems that thrashing in one’s sleep an important diagnostic symptom for Parkinson’s. In a…

People with early Parkinson’s disease are at a higher risk of developing later cognitive problems if they are overweight, have symptoms of depression or anxiety, or have sleep issues or often feel sleepy during the day, a study has found. Recognizing these signs early on, and identifying those at…

The number of people with early-stage Parkinson’s disease who reported sleep disturbances increased over the course of a five-year longitudinal study, with insomnia being the most common sleep problem among this patient population. The frequency of other sleep problems such as…