Author Archives: Joana Carvalho

Plant Compound Berberine May Boost Brain Function

Scientists have found that berberine, a natural plant compound that has been used in China as an over-the-counter medicine for diarrhea, can promote the production of l-dopa, a precursor of the brain chemical dopamine that is missing in patients with Parkinson’s disease, in the gastrointestinal tracts of mice. The…

Yumanity Shares Update on Potential Treatment YTX-7739

YTX-7739, a potential disease-modifying therapy for Parkinson’s disease, was safe, well-tolerated, and found to have a favorable pharmacological profile when given to a group of healthy volunteers. Yumanity Therapeutics provided those early findings from a recently completed single ascending-dose (SAD) Phase 1 clinical trial. Based on the results, Yumanity…

Investment Backs Vibrating Device That Eases Motor Symptoms

The Imperial College Investment Fund (ICIF) has invested £205,000 (about $283,000) in Charco Neurotech to support the development of CUE1, a non-invasive wearable device that uses controlled vibration to ease stiffness and slowness of movement in people with Parkinson’s disease. According to Lucy Jung, former student at…

Research Targets Misfolded Alpha-synuclein

Scientists at Cognition Therapeutics have found that compounds that are able to dampen the activity of sigma-2 receptors — receptors that are part of a network that controls the destruction of misfolded proteins — are highly effective at preventing molecule trafficking defects driven by the presence of misfolded alpha-synuclein inside…

FDA Approves Gocovri as Add-On Therapy for Off Episodes

Gocovri (amantadine) has been approved by the U.S. Food and Drug Administration (FDA) as an add-on therapy for off episodes in people with Parkinson’s disease. Adamas Pharmaceuticals, which developed the therapy, announced its approval in the U.S. for Parkinson’s patients currently taking levodopa and/or carbidopa. Off…

Hoffmann Reflex Test Useful During DBS Surgery

Scientists have found that the Hoffmann reflex — a test often used to evaluate reflexes in the upper extremities — can be used as a biomarker to assess the correct placement of electrodes during deep brain stimulation (DBS) surgery in patients with advanced Parkinson’s disease. This reflex test,…