Alterations in certain types of fat in a brain area called the substantia nigra may result in elevated levels of the GPNMB protein and drive neurodegeneration in Parkinson’s disease patients, according to Harvard researchers. The study, titled “The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson’s disease patients…
A new process to select and purify stem cells that hold therapeutic potential to replace dopamine-producing neurons may hasten clinical development of this promising avenue to treat Parkinson’s disease. Upon being transplanted, these cells promoted dopamine production and reduced the severity of disease-related motor symptoms in an animal model…
Intramuscular treatment with Xeomin (incobotulinumtoxinA) decreases tremor severity and improves hand function in patients with essential tremor of the upper limbs, according to Phase 2 trial results. Results of the trial, titled “Efficacy and safety of incobotulinumtoxinA for upper-limb essential tremor in a randomised, double-blind,…
Patients likely to have prodromal, or early, Parkinson’s disease tend to have a higher prevalence of pain, according to a new study. The findings indicate that pain may be a relevant disease marker before the appearance of motor disturbances. The study, “Pain: A marker of prodromal Parkinsons disease?”…
An analysis of the protein content in tears may offer a non-invasive and inexpensive way of identifying people with probable Parkinson’s disease. A study led researchers at the Keck School of Medicine of the University of Southern California reports that Parkinson’s patients have different levels of alpha-synuclein protein in tear fluid…
A newly developed rat model combining elevated levels of alpha synuclein — a key protein in both Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) — and related pathological changes may provide new insights into both disorders, according to a new study. The research, “…
Nilotinib can modulate dopamine levels and metabolism, as well as prevent the formation of toxic alpha-synuclein aggregates, according to recent data from a Phase 2 clinical trial. These findings suggest that Novartis’ investigational therapy has the potential to promote long-term benefits in patients with Parkinson’s disease. The study, “…
Apathy is prevalent problem in Parkinson’s disease, but it is more evident in patients’ behavioral and social habits than in their emotional or cognitive ones, researchers in the U.K. report. Their study, Differential impact of behavioral, social, and emotional apathy on Parkinson’s disease,” also linked behavioral and social apathy to…
A whey protein-based nutritional supplement improved motor functions in patients with Parkinson’s or parkinsonism who were engaged in an intensive physical rehabilitation program, according to clinical trial results. The study, “PROtein, LEucine And vitamin D Enhancing Rehabilitation (PRO-LEADER) in patients with Parkinson’s disease or parkinsonism:…
Subthalamic deep brain stimulation (STN-DBS) seems to be a long-term, effective, and safe therapeutic option for patients with advanced Parkinson’s disease, new studies report. STN-DBS is a non-destructive surgical treatment for Parkinson’s, in which a battery-operated device that generates electrical impulses is implanted to specific regions of the…
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