The U.S. Food and Drug Administration (FDA) is asking for more information concerning the safety of  IPX203, an extended-release oral formulation of carbidopa and levodopa, before a final approval decision in treating Parkinson’s disease symptoms can be made. In a complete response letter to Amneal Pharmaceuticals,…
A one-hour group singing session significantly eased problems with walking and posture, as well as tremors, in adults with Parkinson’s disease who were on stable medication, a small study reported. While no significant benefits were seen for speech and facial expression, or for bradykinesia (slowness of movement), patients taking…
Regular treadmill exercise significantly reduced the aggregation and spread of alpha-synuclein in the brain — a hallmark of Parkinson’s disease — prevented neurodegeneration, and lessened motor deficits in a mouse model of Parkinson’s, a study showed. These benefits were found to be associated with the activation of a receptor…
A new Parkinson’s disease mouse model — carrying a common disease-associated mutation in both copies of the LRRK2 gene — recapitulates some motor and behavioral symptoms of the disease, while also showing mitochondrial abnormalities, a study showed. Problems in mitochondria, known as the powerhouses of the body’s cells, are increasingly seen…
Daily oral supplementation with açai berry lessened motor and nonmotor deficits in a mouse model of Parkinson’s disease, a study showed. These benefits were accompanied by a reduction in neuroinflammation, alpha-synuclein protein accumulation, a type of cellular damage called oxidative stress, and dopaminergic neuron loss — all implicated in…
Scientists have created a roadmap of the maturation steps of dopaminergic neurons — the nerve cells progressively lost in Parkinson’s disease — from human stem cells. Their work may help identify potential ways to optimize this process in the lab for new Parkinson’s cell therapies. “Our findings provide valuable…
Drinking more than three beers or about three large glasses of wine per week is associated significantly with higher iron levels in several brain regions, which is linked to worse cognitive function. That’s according to a study from the United Kingdom involving nearly 21,000 people — likely representing the largest…
Carrying the G2385R variant in the LRRK2 gene is associated with a three times higher risk of developing Parkinson’s disease among Chinese adults older than 50, according to a 10-year population-based study. Carriers of this mutation who were not diagnosed with Parkinson’s showed a trend toward greater motor…
Researchers have developed a new suppressor of cyclin-dependent kinase 5 (Cdk5) — an enzyme whose activity is associated with neuropsychiatric and neurodegenerative conditions — that can robustly enter the brain and appears to be more potent than previous, similar molecules. When injected into the bloodstream, the new molecule, named 25-106,…
An individualized, tablet-based, at-home physiotherapy training program may help stabilize the benefits of a multidisciplinary inpatient treatment approach in people with Parkinson’s disease, a recent study suggests. While differences between patients receiving standard care following discharge and those undergoing the nine-month, at-home program generally failed to reach statistical…
Get regular updates to your inbox.