Author Archives: Marta Figueiredo PhD

Discovery May Explain Conflicting DBS Results

The mesencephalic locomotor region, a brain region previously thought to control only walking and other forms of locomotion in vertebrates, also regulates postural changes and other movements, according to a study in mice. “It was surprising that within this region, which everybody has linked to locomotion, many of the neurons…

Worse Early Non-motor Symptoms Predict Faster Function Decline

The number and severity of non-motor symptoms increase during the early stages of Parkinson’s disease, and are significantly associated with age and motor symptoms, according to a study in China. The findings showed that a higher non-motor symptom burden in early Parkinson’s was significantly associated with a faster progression…

SLS-004 Lowered Alpha-synuclein Levels in Mice

SLS-004, Seelos Therapeutics’ experimental epigenetic editing therapy for Parkinson’s disease, effectively reduced the production of alpha-synuclein — the protein that accumulates in toxic clumps in Parkinson’s — in the brains of healthy mice. Epigenetic modifications refer to the addition of chemical marks to DNA by a group of specialized…

2 Nanoparticles Show Potential to Prevent Amyloid Clumping

Nb10 and TiNb9, two nanoparticles of a particular chemical element, effectively reduce the formation of toxic amyloid fibrils — a hallmark of Parkinson’s and Alzheimer’s diseases, a lab dish study showed. Particularly, these nanoparticles suppressed the assembly of toxic clumps of S100A9, a pro-inflammatory molecule that is central to…

COVID-19 Lockdown Increased Impulse Control Disorders in Spain

Impulse control disorders (ICDs) among people with Parkinson’s disease were significantly more common and more severe after a COVID-19-related lockdown than before the pandemic, according to a small study in Spain. Also, patients who developed ICDs in the post-lockdown period were younger, developed Parkinson’s at a younger age, or had more…

Blood-brain Barrier Model May Have Parkinson’s Application

A new human-derived model of the blood-brain barrier (BBB) — a highly selective and protective membrane whose dysfunction is linked to Parkinson’s disease — enables researchers to monitor in detail cellular events upon stress, inflammation, and therapy administration, a study shows. This model allowed the assessment of the protective effects of…

LL-37 Suppresses Alpha-synuclein Clumping in Parkinson’s

LL-37, a natural antimicrobial molecule present in the brain and gut, selectively binds to harmful clumps of the alpha-synuclein protein — a hallmark of Parkinson’s disease — and prevents their further aggregation and toxic effects in lab-grown nerve cells, a study shows. The discovery of such a strong suppressor…

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