ABBV-951, AbbVie‘s experimental under-the-skin formulation of levodopa/carbidopa, was generally well-tolerated and increased average “on” time by more than three hours among people with Parkinson’s disease. Those results from a Phase 3 open-label clinical trial were shared at the 8th European Academy of Neurology (EAN) Congress in Vienna, Austria, in…

AbbVie has submitted a new drug application to the U.S. Food and Drug Administration (FDA) for ABBV-951 (foscarbidopa/foslevodopa), its investigational under-the-skin formulation of carbidopa/levodopa for the treatment of motor fluctuations in advanced Parkinson’s disease. If approved, ABBV-951 will provide patients in the U.S. with a first-of-its-kind, 24-hour, continuous…

ABBV-951, a continuous infusion formulation of levodopa/carbidopa, brought comparable levels of levodopa into the bloodstream of healthy volunteers as surgically implanted levodopa-carbidopa intestinal gel (LCIG), a Phase 1 study confirmed. Because the delivery of doses can be tailored to a patient’s needs, this alternative form of delivery — a portable…

Under-the-skin infusions of low-dose apomorphine using a wearable device called h-Patch may help in avoiding off periods and improving motor function in Parkinson’s patients, Valeritas, the technology’s developer, reports. A preclinical study found that apomorphine delivered using h-Patch could be detected in the blood within two hours, with a…

D-mine Pump, a portable micro-infusion pump designed to continuously deliver apomorphine under the skin (subcutaneously) to patients with Parkinson’s disease, has received the European CE approval and now will be marketed in several European countries. CE means “European Conformity,” a certification mark that indicates conformity with European health, safety,…

NeuroDerm’s Phase 2 Parkinson’s disease (PD) trial of ND0612H — a continuous infusion of levodopa and carbidopa delivered by a small belt pump — has met both primary and key secondary endpoints by demonstrating that the treatment effectively reduced “off-time” and increased the number of patients with advanced…