PNA5 targets Parkinson’s cognitive symptoms, may slow decline

Mice modeling Parkinson’s disease performed better on tests of memory and spatial recognition when given daily under-the-skin injections of PNA5, an experimental ProNeurogen therapy targeting cognitive symptoms — suggesting the treatment’s potential to slow cognitive decline in patients. In this preclinical study, researchers from the University of Arizona…

Top 10 Parkinson’s stories of 2023

Throughout 2023, we at Parkinson’s News Today brought you coverage of the latest scientific advances and developments in treatments for Parkinson’s disease. Here we’ve compiled a list of the top 10 most-read stories published this past year. We look forward to continuing to share more developments with you in…

Suppressing Enzyme Synuclein Nitrase Could Lead to New Therapies

Nitrase Therapeutics showed suppressing the activity of an enzyme called synuclein nitrase reduces toxic clumps of the alpha-synuclein protein and normalizes the electrical activity of dopamine-producing, or dopaminergic, neurons derived from Parkinson’s patients. The accumulation of toxic alpha-synuclein clumps is the underlying cause of the progressive death of…

Zonisamide for Epilepsy May Ease Parkinson’s Motor Symptoms: Study

Zonisamide, an epilepsy medication approved in the U.S. for some seizure-causing disorders, may reduce the motor symptoms of Parkinson’s disease, according to a review study of clinical trial data. The findings also suggest the therapy is associated with improvements in daily life activities for Parkinson’s patients, and with reductions…

Irisin Hormone Shows Potential as Parkinson’s Treatment

The hormone irisin prevents the buildup of toxic alpha-synuclein protein, leading to the preservation of nerve cells and easing motor symptoms in a mouse model of Parkinson’s disease, a study has found. Experiments showed the hormone had an ability to facilitate the breakdown of toxic alpha-synuclein through lysosomes, the…

Machine Learning IDs Approved Meds With Potential for Parkinson’s

Screening a large database with machine learning tools helped scientists identify approved medicines for other diseases that reduced the risk of developing Parkinson’s, a study reported. According to researchers, these potential Parkinson’s disease therapies “deserve to be confirmed” in larger studies. “Drug repurposing or repositioning is the application of…