The Parkinson’s and Movement Disorder (PMD) Alliance, a U.S.-based nonprofit, is seeking participants willing to take part in an online survey about the experiences of patients and caregivers with off time in Parkinson’s disease. Off time, or periods when medication wears off and symptoms return,…

Adding Cerevance’s investigational oral therapy solengepras (CVN424) to standard Parkinson’s disease treatment significantly decreased off time, when symptoms return or worsen, according to the data from a completed Phase 2 trial. The trial met its main efficacy goal, with a reduction in average off time at the…

Note: This story was updated Oct. 7, 2024, to correct references to the open-label extension study of the BounDNless trial. A year of treatment with ND0612, an investigational liquid formulation of levodopa/carbidopa continuously administered as an infusion under the skin, sustainably reduced the periods of time when motor symptoms…

DopaFuse, a continuous oral levodopa-carbidopa delivery system, led to more stable levels of medication in the blood and better control of symptoms for people with Parkinson’s disease in a small Phase 2 study. Warren Olanow, MD, a neurologist at Mount Sinai, presented findings from the trial at the…

Most people with Parkinson’s disease treated with SPN-830, an apomorphine infusion pump, report improvement in their health status. SPN-830 also reduced “off” time, when symptoms are not being adequately controlled, by an average of about three hours a day. That’s according to new results from an open-label…

Using Cerevance’s oral CVN424 as an add-on therapy for Parkinson’s motor symptoms led to a significant and meaningful dose-dependent reduction in “off” time — periods when symptoms reappear or worsen — data from a Phase 2 study show. The trial also met its safety objectives, according to a…

ABBV-951, an under-the-skin formulation of levodopa/carbidopa, outperformed the standard oral therapy at controlling Parkinson’s symptoms in advanced disease patients in a Phase 3 clinical trial, top-line results show. “These data are promising and demonstrate positive results on a key endpoint used to assess efficacy of treatments for patients with…

Treatment with zonisamide — an approved epilepsy medication — can reduce “off” time without worsening treatment side effects in people with Parkinson’s disease, a new analysis of Japanese clinical trial data shows. Notably, the use of zonisamide did not increase dyskinesia, the uncontrolled, involuntary movements common among…

The Michael J. Fox Foundation (MJFF) has released a new suite of free educational resources that focuses on so-called “off” periods when Parkinson’s disease symptoms reappear or worsen as medications wear off. These new resources, available at michaeljfox.org/off, offer patients and their families tips for managing “off” time,…

The U.S. Food and Drug Administration (FDA) has approved Ongentys (opicapone) as an oral, add-on daily treatment for Parkinson’s disease patients experiencing off periods while on a levodopa/carbidopa regimen. The approval is for 25 mg and 50 mg capsules, either taken once a day. It comes after…