Subcutaneous, or under-the-skin, injections of COYA 302, a combination therapy in development by Coya Therapeutics, were found to reduce excessive inflammation and immune cell activation in a mouse model of Parkinson’s disease. These beneficial effects were observed in the nigrostriatal pathway, a brain circuit responsible for motor control,…

BioVie is planning to launch in late summer a Phase 2b clinical trial of NE3107, its investigational anti-inflammatory small molecule, as an initial and stand-alone treatment for Parkinson’s disease, the company announced in a release. The trial aims to recruit between 100 and 150 newly diagnosed Parkinson’s…

Neuropore Therapies has received a $4.8 million grant from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) to develop a small molecule that will block the activation of a protein receptor, called toll-like receptor 2 (TLR2), that fuels inflammation in people with Parkinson’s disease. The grant will support…

Parkinson’s UK and Domainex are teaming up to develop small molecules aimed at lessening chronic brain inflammation and slowing the progression of Parkinson’s disease. “We are thrilled to have been selected by Parkinson’s UK to work on this promising project which has the potential to improve the…

Parkinson’s UK is investing up to £3 million (about $3.96 million) over the next two-and-a-half years to support research into inflammation that could help in developing therapies to slow the progression of Parkinson’s disease. The funding will come through the organization’s Virtual Biotech program — the therapy development…

New research suggests that brain inflammation is the likely reason antibody-based therapies are ineffective in clinical trials for people with Parkinson’s and Alzheimer’s diseases. The findings show that the binding of the antibody to its target protein — in the case of Parkinson’s disease the misfolded alpha-synuclein —…

Although there isn’t currently sufficient evidence to draw definitive conclusions, it is possible that people who survive COVID-19 may be at increased risk of Parkinson’s disease, researchers from Brazil argued in a recent paper. More research is needed to examine this idea, which points to a need for…

Alkahest announced the dosing of a first patient in the Phase 2 trial for its Parkinson’s therapy AKST4290, an oral tablet aiming to ease the inflammation that can aggravate disease symptoms. The efficacy and safety trial, called AKST4290-211 or TEAL (2019-001657-42), will measure AKST4290’s benefits in motor function and…

Tiny and traceable man-made crystals, known as quantum dots, may be useful in carrying toxins to select cells in the brain, allowing researchers to better understand Parkinson’s neurodegenerative processes by being able to model and visualize them, researchers in Canada report. Their study, “Quantum dot conjugated saporin activates…

The Parkinson’s Foundation and the American Parkinson Disease Association (APDA) have announced a combined $5.9 million in research grants. For its part, the Foundation is investing $4.2 million in 46 grants to advance promising Parkinson’s disease investigations into new therapies and how the disease works. It also…