Parkinson’s UK has opened a survey aimed at understanding the experiences of caregivers of people who have Lewy body dementia or Parkinson’s disease dementia. The survey seeks to shed light on the support caregivers receive, and caregivers’ and patients’ experiences with the health and social care system in…

A planned Phase 2 clinical trial evaluating ANVS401, Annovis Bio‘s lead investigational therapy for people in the early stages of Alzheimer’s and Parkinson’s disease, has received approval from a central institutional review board (IRB). An IRB is an administrative body responsible for protecting the rights and welfare of human research…

People who live less than 50 meters (about 54 yards) from major roads or 150 meters (164 yards) from a highway have a higher risk of developing Parkinson’s disease or other neurodegenerative disorders, according to a Canadian study. Meanwhile, green spaces such as parks seem to offer protection and lower…

Biogen is adding Pfizer’s PF-05251749 — a regulator of the body’s inner clock — to its group of potential disease-modifying therapies for Parkinson’s and Alzheimer’s diseases. Biogen plans to test PF-05251749 in an upcoming Phase 1 clinical trial as a treatment to correct irregular sleep wake…

A mathematical model created to more effectively prevent protein clumping, widely thought to underlie diseases like Parkinson’s, found that different potential treatments work best at different disease stages. As such, this model may help in designing and timing the use of therapies against protein aggregates, and in testing them in…

Using ultrasound coupled with the intravenous injection of microbubbles lessened brain damage in a mouse model of early Parkinson’s and may provide a noninvasive way to successfully deliver therapies into the brains of people with the disease, a study reports. A clinical trial with Alzheimer’s disease patients has been…

A reader recently posed the following question: “Why are there never any comments on dementia in regards to Parkinson’s disease? It is very real, and 40 percent of Parkinson’s patients deal with it.” So, I began looking into it. My answer could have been, “Because I don’t want…

Mission Therapeutics and AbbVie have established a new partnership aimed at developing specific inhibitors targeting deubiquitylating enzymes, or DUBs, for the treatment of Alzheimer’s and Parkinson’s diseases. DUBs are a large family of important enzymes that regulate the protein degradation process, some of which are involved in the…

Different brain cells determine which form of alpha-synuclein will be responsible for different Parkinson’s-related disorders, a new study suggests. The research, “Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies,” was published in the journal Nature. Aggregates of the protein alpha-synuclein are characteristic of Parkinson’s, Lewy body…

Anavex Life Sciences is planning to open a Phase 2 clinical trial testing Anavex 2-73, a potential oral treatment for patients with Parkinson’s disease dementia (PDD), this year. Anavex 2-73 aims to treat PDD by binding to the sigma-1 receptor, located in a cellular structure called the endoplasmic reticulum…