Before deep brain stimulation (DBS), a surgical treatment for Parkinson’s disease, made it possible for guitarist Fabio Dwyer to again play and return to his livelihood in Canada, all had seemed lost. Be it performing, composing, or teaching, Dwyer’s world was ensconced in music. He had helped…
News
ProMIS Neurosciences announced arriving at a lead candidate vaccine against the misfolded alpha-synuclein protein, which the company plans to develop as a treatment for Parkinson’s disease and related disorders. The potential vaccine, known as PMN400, is moving into preclinical testing in animal models of Parkinson’s. “We are…
A decade after its establishment, the Friends of Parkinson’s — a group that supports, educates, and advocates for those living with the progressive neurodegenerative disorder — is asking for donations to allow it to grow and be of greater help. Jamillah Ali-Rahman, who founded the Nevada-based nonprofit in 2014,…
Air pollution may increase the risk of Parkinson’s disease, particularly in people who are already genetically predisposed to develop the disorder, a study shows. “We discovered that individuals with elevated genetic susceptibility and heightened exposure to air pollutants faced a markedly heightened risk of [Parkinson’s],” its researchers wrote. “Therefore,…
Levodopa Cyclops, an inhaled version of levodopa that PureIMS is developing as a treatment for off episodes with Parkinson’s disease, safely delivers levodopa to the body faster than an existing inhaled formulation of the therapy. That’s according to results from a company-sponsored clinical trial (NCT06037590) comparing…
Scientists at Purdue University are advancing in lab studies multiple small molecule compounds aiming to prevent the protein aggregation associated with Parkinson’s, Alzheimer’s, and type 2 diabetes, and to safely get rid of existing clumps. Protein aggregation is the term for when proteins — usually abnormal or misfolded…
In a new approach to drug discovery, seven molecules, or “hits,” that may treat familial Parkinson’s disease were identified in the first open science competition run by the Canadian nonprofit Conscience. Launched with support from the global public-private partnership Structural Genomics Consortium (SGC) and a grant from…
3D “mini-brains,” or brain organoids, derived from people with Parkinson’s disease and primary progressive multiple sclerosis (MS) are now at the International Space Station (ISS) as part of ongoing research in the unique effects of space on the human brain. How brain cells interact in microgravity, a condition…
Shingles, an infectious disease marked by a painful skin rash with blisters, wasn’t associated with an increased risk of Parkinson’s disease, according to a study of more than 1 million U.S. veterans. “We showed no evidence of an increased risk of incident [Parkinson’s disease] after [shingles] in a large,…
Reduced activity of the RIT2 gene in a subtype of nerve cells — regardless of whether they produce dopamine — may be implicated in the development of Parkinson’s disease, according to a study that measured gene activity in more than 300,000 individual brain cells. The protein encoded by RIT2…
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