A protein called NEMO can dock to misfolded forms of alpha-synuclein — the protein whose toxic aggregates damage and kill nerve cells in Parkinson’s disease — sending them off for recycling in cellular structures called lysosomes, a study reports. But problems with this waste disposal process can lead to…
Monitoring symptoms at home using smartwatch-smartphone technology collected individual profiles of tremor and activity fluctuations among people with advanced Parkinson’s disease being treated with levodopa. The technology can provide useful information to improve treatments and patient outcomes and, by combining it with telemedicine and other digital health tools, could…
A plant compound called afzelin lessened motor abnormalities in a rat model of Parkinson’s disease, a study reports. Afzelin, found in certain plants like some water lilies and trees, has been shown to have a variety of pharmacological properties, including antioxidant and anti-inflammatory effects, that might benefit people with…
Treatment with AB-1005 (AAV2-GDNF), AskBio’s investigational gene therapy, was safe and well tolerated among patients with mild to moderate Parkinson’s disease, according to top-line results from a Phase 1b clinical trial. The company, wholly owned by Bayer, has also completed an 18-month data collection which demonstrated the…
A three-month exercise program focusing on Brazilian dance led to greater gains in lower limb strength among Parkinson’s disease patients than Nordic walking or deep-water exercise programs, according to a clinical trial report. Most measures of motor performance, cognitive function, and quality of life were unaltered by any of…
A growing need for local doctors able to compassionately, as well as accurately, diagnose Parkinson’s disease exists, as the number of people being given a Parkinson’s diagnosis is rising in the U.S. while access to movement disorder specialists — trained in knowing how best to deliver such news…
Richard Wyse, MD, director of clinical development at Cure Parkinson’s, is among those in the United Kingdom (U.K.) recognized for their services to the public through inclusion on His Majesty The King’s New Year’s Honours List. Wyse, recognized for his work with Parkinson’s disease, is among…
Exposure to nanoplastics, micro-sized fragments of plastic waste found in the environment, mimicked the signs and symptoms of Parkinson’s disease in tiny worms and in human nerve cells in the lab, a study reported. Low concentrations of nanoplastics were found to penetrate the walls of the worms’ intestines and…
Using IPX203, an extended-release formulation of carbidopa/levodopa (CD/LD), was associated with a sustained control of symptoms for Parkinson’s disease patients who participated in the open-label extension of the RISE-PD Phase 3 trial. Final results from the nine-month extension study (NCT03877510) indicate dose adjustments and side effects were…
A team led by scientists in the Netherlands is proposing a new screening strategy to test whether pesticides or other chemicals might increase the risk of Parkinson’s disease. “We are still largely in the dark about the safety of these substances. The current admission criteria for pesticides provide insufficient…
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