A compound called IU1 may improve the body’s ability to maintain healthy proteins by boosting two critical processes that play a role in removing damaged proteins from cells, a study shows. The findings could have implications for age-related conditions like Parkinson’s disease. The study, “Pharmacological inhibition of…
Treatment with tavapadon as a fixed-dose single therapy significantly improved motor function in early stage Parkinson’s disease, according to top-line data from a completed Phase 3 trial. Full results from TEMPO-1 (NCT04201093) will be presented at future medical meetings and support regulatory submissions toward the investigational therapy’s approval.
A mutation in the RAB32 gene, which has been previously associated with Parkinson’s disease, was found in a significant number of individuals participating in an international study. Specifically, researchers found this mutation more than 100 times more prevalent in Parkinson’s patients than in the general population. These data came…
Administration of tiny cargo-carrying vesicles called exosomes derived from human umbilical cord blood eased motor and cognitive dysfunction in a mouse model of Parkinson’s disease, according to a recent report. The exosomes were able to prevent neurodegeneration, promote nerve cell regeneration, and protect against dysregulated cellular processes implicated…
Pramipexole, the active ingredient in the Parkinson’s disease therapy Mirapex, appears to overactivate a brain region known as the external globus pallidus — findings that could explain the poor decision-making and impulse control that occurs as a side effect of the medication in some patients — according to…
A small compound that acts as a molecular glue can activate a protein that’s often mutated in people with early-onset Parkinson’s disease, a study finds. By activating parkin, the compound enables the protein to perform its function of removing damaged mitochondria, thereby helping maintain the health of brain cells.
A new mouse model replicates the symptoms of Parkinson’s disease and its progression in patients, beginning with diminished smell and other disease nonmotor symptoms that are early signs of the neurodegenerative disorder and often evident before problems with gait and balance arrive, scientists report. Many mouse models overexpress…
Parkin, a protein linked to Parkinson’s disease that’s lost in certain types of cancer, triggers the release of signaling molecules that activate and attract immune cells to fight tumors, according to a study led by researchers at The Wistar Institute in Philadelphia. “Parkin has only recently been implicated for…
Crexont, an extended-release formulation of levodopa and carbidopa, is now available in pharmacies across the U.S. for people with Parkinson’s disease. The Parkinson’s therapy, marketed by Amneal Pharmaceuticals is designed to maintain steady levels of levodopa and carbidopa in the body, extending periods of optimal symptom management,…
A National Institutes of Health (NIH) grant will fund the creation of a brain-on-a-chip technology, a microengineered device containing nerve cells and blood vessels to help scientists more fully understand how neurodegenerative diseases like Parkinson’s and Lewy body dementia affect their ability to function. Jungwook Paek, PhD,…
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