News

Pretzel advances mitochondrial therapy with PX578 Phase 1 trial

Pretzel Therapeutics has launched a Phase 1 clinical trial to study PX578, a therapy designed to boost the function of mitochondria, the cell’s energy-producing powerhouses, and address conditions caused by faulty energy production. These include rare genetic conditions and neurodegenerative disorders like Parkinson’s and Alzheimer’s. The…

Parkinson’s therapy slows alpha-synuclein spread in mice: Data

Nitrase Therapeutics’ NDC-0524, an antibody therapy for Parkinson’s disease, significantly reduced alpha-synuclein aggregation and spreading in mouse models of the disease, according to preclinical data released by the company. The antibody targets nitrated alpha-synuclein, a misfolded form of the protein that forms toxic clumps in dopaminergic neurons, the nerve cells…

Common medications may delay Parkinson’s disease onset: Study

Medications commonly used to treat conditions such as high blood pressure, high cholesterol, and pain may delay Parkinson’s disease onset, according to a U.S. study. Analyses found that anti-hypertensives such as adrenergic blockers, cholesterol-lowering statins, and non-steroidal anti-inflammatory drugs (NSAIDs) were strongly associated with later onset disease. In contrast,…

Cognitive tasks while walking distinguish MSA, Parkinson’s: Study

Performing cognitive tasks while walking may help distinguish between early Parkinson’s disease and multiple system atrophy (MSA), a neurodegenerative disorder with similar symptoms, a study suggests. MSA patients had more walking impairments alongside higher brain activity during cognitive tasks while walking than Parkinson’s patients, the research shows. “We…

Supporters focus on empowerment, education this awareness month

April is Parkinson’s Awareness Month and, in the U.S. and across the globe this year, patients, caregivers, medical professionals, and advocates will be focusing their attention on helping to empower those living with the neurological disease by providing educational resources, fostering community, and providing opportunities to get involved. World Parkinson’s…