Gain Therapeutics‘ investigational compounds were able to lessen motor symptoms in a rat model of GBA1-associated Parkinson’s disease and also decrease the levels of alpha-synuclein accumulation in nerve cells — two hallmarks of the neurodegenerative disease. The two candidates — GT-02287 and GT-02329 — are…
Alligator Bioscience and BioArctic AB have partnered to research and develop new therapies for neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s. “We are very pleased that BioArctic has recognized the power of Alligator’s proprietary phage display libraries which have been successfully used to generate Alligator’s…
Parkinson’s disease does not appear to make a person more susceptible to infection with the COVID-19-causing virus, or at risk of poorer outcomes, according to a study in a small hospitalized patient group in Italy when the pandemic struck. The observational study, “The impact of SARS-COV2 infection on…
Centogene announced plans to recruit 2,500 more patients this year into its observational Rostock International Parkinson’s Disease (ROPAD) study of how genetic factors contribute to the development of Parkinson’s. “We recently reached a significant study milestone, but this is just the beginning,” Peter Bauer, MD, Centogene’s chief genomic…
Levels of a protein involved in the transport of brain signaling molecules in dopamine-producing neurons appear to be sex specific — higher in female than in male animal models and human cells — and to protect against age-related neurodegeneration, a study reported. Given that older age and male sex are risk factors for …
Scientists have identified genetic variations that are associated with different rates of disease progression in people with Parkinson’s disease. The findings suggest that the genetic changes that affect disease progression are distinct from those that impact whether a person will get Parkinson’s at all, and that disease initiation and…
A new research training program called NeuroInsight is seeking to teach scientists in the data analytics and neuroscience skills needed to research Parkinson’s disease and other neurological conditions. The program received a €4.7 million ($5.64 million) grant from the Marie Skłodowska-Curie Actions COFUND, a European fund that provides financial…
An experimental deep brain stimulation (DBS) system can continuously monitor brain activity in Parkinson’s disease patients as they go about their daily activities, with the information it produces used to adjust stimulation delivered by an implant device, the research team that developed it reported. “This is really the first…
The Parkinson’s Foundation is investing an additional $10 million to support research, care, and education programs in order to improve the lives of people with Parkinson’s disease in the U.S. Part of the funding will go toward the PD GENEration: Mapping the Future of Parkinson’s Disease initiative,…
Treatment with investigational oral therapy BIIB122/DNL151 safely lowered the activity of disease biomarkers that reflect LRRK2 activity, a protein whose mutations are associated with Parkinson’s disease, according to results from two Phase 1 clinical studies. Plans are being put in place to advance the therapy into late-stage clinical testing…
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