Researchers have found a molecular link between Parkinson’s disease and melanoma, a type of skin cancer, in the form of protein clumps. Their study results were presented at the spring meeting of the American Chemical Society this week. A hallmark of Parkinson’s disease is the buildup of alpha-synuclein protein…
Dopamine-releasing cells in the brain, much like most other hormone-producing cells, have a self-regulating feedback mechanism that controls their activity, researchers have discovered. That is, healthy nerve cells themselves determine how much dopamine will be released, the research team found, in contrast with the prevailing view that nearby cells “control”…
BlueRock Therapeutics has received permission from Health Canada to start a Phase 1 clinical trial evaluating DA01, an investigational cell therapy that aims to restore neurons lost to Parkinson’s disease. This clearance comes three months after the U.S. Food and Drug Administration (FDA) accepted the company’s request…
Aptinyx‘s Phase 2 clinical trial evaluating its investigational oral compound NYX-458 for the treatment of cognitive impairment and mild dementia associated with Parkinson’s disease is resuming patient screening after a temporary pause due to the COVID-19 pandemic. Recruitment is underway at multiple locations in the United States.
A neural map of the brain region central to Parkinson’s disease opens the possibility of new ways to treat this disorder and others that stem from damage to the nerve cells found there. The map, detailed in a recent study, might enable researchers to understand how specific nerve damage…
A new research project aims to determine whether medications developed to treat depression might be viable candidates for easing some troubling side effects of treatments for Parkinson’s disease, including levodopa. Parkinson’s is caused by the death or dysfunction of cells in the brain that make a neurotransmitter (brain signaling…
Invitae has launched a new genetic testing program, at no charge to participants, to test adults suspected of having — or at risk of developing — neurodegenerative disorders, including Parkinson’s disease. The Adult Neurodegenerative Disorders sponsored testing…
Exercise can slow early cognitive decline in Parkinson’s disease patients who have a variant of the APOE gene, called APOE4, a recent study has found. “Additional research is needed to confirm our findings, but these results would support the use…
New research suggests that brain inflammation is the likely reason antibody-based therapies are ineffective in clinical trials for people with Parkinson’s and Alzheimer’s diseases. The findings show that the binding of the antibody to its target protein — in the case of Parkinson’s disease the misfolded alpha-synuclein —…
Microbleeds found in the brains of people with Parkinson’s disease by magnetic resonance imaging (MRI) scans were associated with cognitive decline, a study demonstrated. Higher levels of a microbleed-associated biomarker also were found in patients with dementia. Moreover, a statistical analysis found the…
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