A £1.375 ($1.9) million grant from the Edmond J. Safra Foundation will support a pioneering clinical trial aimed at speeding the development of new therapies for Parkinson’s disease. “This project will revolutionise the way we perform clinical trials of potentially disease-modifying drugs for people with Parkinson’s,” Thomas Foltynie, PhD, MD, a…
A protein secreted by stem cells, known as pentraxin 3 (PTX3), promoted the repair of nerve cells damaged as a consequence of Parkinson’s disease in a mouse model, a study reported. These findings support further work into PTX3 as a potential therapy to slow or halt disease progression, its researchers noted.
Middle-aged and older autistic adults with no intellectual disabilities reported more prevalent Parkinson’s disease-like features — referred to as parkinsonism — compared with the general population, a study found. These findings provide important knowledge about aging disorders such as Parkinson’s among older people with autism spectrum disorder…
People who are gay, bisexual, or transgender with Parkinson’s disease or other movement disorders can be reluctant to disclose their sexual or gender identities for fear of being denied treatment or enrollment in clinical trials, a study found. Research is limited into this growing patient group, and best practice guidelines…
The formation of toxic clumps of the protein alpha-synuclein, a hallmark of Parkinson’s disease, was not affected by reducing levels of tau, a protein that also forms aggregates in both Parkinson’s and Alzheimer’s disease, a mouse study suggested. These results imply that the role of tau in…
The U.S. Food and Drug Administration (FDA) has approved a Phase 3 trial to test multiple infusions of fat-derived mesenchymal stem cells — ones obtained from healthy donors — in people with Parkinson’s disease. The Hope Biosciences Stem Cell Research Foundation (HBSCRF), which received the authorization, already has a…
Smoking history may not influence the severity of symptoms in Parkinson’s disease, a small study suggests. Moreover, in some individuals, exposure to cigarette smoke may worsen motor symptoms, which could lead patients to quit smoking and explain why smoking is more common among people without the disease. The study,…
Exposing a molecule called PAI to light altered its shape, triggering an interaction with protein receptors — ones also associated with Parkinson’s disease — that control brain function, a study in mice demonstrated. The findings support the development of light-sensitive methods to understand the underlying impact of Parkinson’s on the…
A program of jaw-related exercises, coupled with individualized advice for oral hygiene, can improve quality of life as it relates to oral health among people with Parkinson’s disease, a small study reported. The study, “Effect of orofacial physiotherapeutic and hygiene interventions on oral health related quality…
Aleva Neurotherapeutic’s innovative directional deep brain stimulation (DBS) system — called directSTIM — for Parkinson’s disease has been implanted in the first patient participating in a German study. That study, which aims to demonstrate improved outcomes when using this DBS technology in individuals with Parkinson’s and essential tremor,…
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