Two small molecules in the pipeline of Lucy Therapeutics helped nerve cells (neurons) keep their mitochondria healthier and reduced the levels of alpha-synuclein, a protein that builds as toxic clumps in the brain of people with Parkinson’s disease. These molecules, called LucyTx-1209 and LucyTx-1212, also were seen…
News
Enterin has teamed with Parkinson’s UK to launch a Phase 2 trial evaluating the ability of ENT-01, its investigational compound, to lessen Parkinson’s disease-associated dementia. The clinical trial will be led by Parkinson’s Virtual Biotech, the treatment development arm of Parkinson’s UK, and will be conducted at…
A new strategy that combines online cognitive therapeutic games with a noninvasive brain stimulation technique – called COGNISANT – may help boost short-term memory in older people, according to a new study. The findings may prove important for people with Parkinson’s disease who often experience a decline in short-term,…
Researchers have developed a software that can accurately identify people with Parkinson’s disease or multiple sclerosis (MS) from healthy controls based solely on their gait. The software, which analyzes gait video data collected at patients’ homes using simple digital cameras, may provide an inexpensive tool to identify and…
Muna Therapeutics has received a $4.9 million grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to advance  development of its first-in-class small molecules used to halt neuroinflammation and restore nerve cell function in people with Parkinson’s disease. The grant will fund preclinical research into small molecules…
Two clinically-proven speech therapy programs tailored to Parkinson’s disease patients, SPEAK OUT! and The LOUD Crowd, are now available at the Hackensack Meridian Johnson Rehabilitation Institute at Ocean University Medical Center, New Jersey. Both programs, developed by the nonprofit Parkinson Voice Project, are designed to help patients “speak…
Gb Sciences has identified a handful of mixtures that contain just enough  cannabinoids — the active compounds of the cannabis plant — to prevent death in lab-grown nerve cells and help lessen motor symptoms in a zebrafish model of Parkinson’s disease. Out of more than 60 mixtures…
Alpha-synuclein protein clumps — the toxic aggregates related to nerve damage in Parkinson’s disease — vary, including in size, and small fragments appear to drive cellular toxicity compared with larger fragments, a study shows. Its findings were confirmed in post-mortem examinations of brain tissue from Parkinson’s patients, showing smaller clumps…
The risk of developing dementia appears to be higher among people with Parkinson’s disease when compared to age and sex-matched controls, according to the findings of a 25-year follow-up study of more than 1,000 patients in Sweden. The study, “High risk of developing dementia in Parkinson’s disease: a…
Fifty new genes that modified signs of Parkinson’s disease in a fruit fly model have been discovered using a multidisciplinary approach involving genomics, computational tools, and patient sample analysis, a study has reported. Some gene candidates worsened Parkinson’s signs while others conferred neuroprotection, “underscoring their therapeutic potential,” the researchers…
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