SynAgile announced the completion of a Phase 2 clinical trial evaluating DopaFuse, its noninvasive system for the continuous oral delivery of levodopa/carbidopa to people with Parkinson’s disease. Sixteen adults being treated with levodopa/carbidopa (LD/CD) in a tablet form were enrolled in the open-label study into the safety and tolerability…
Alpha-synuclein aggregation — the toxic clumping of proteins in nerve cells that is a hallmark of Parkinson’s disease — starts on the membranes of mitochondria, the so-called powerhouse of a cell, according to work in cell models. “Our study provides insights into what is happening in the earliest stages…
Amneal Pharmaceuticals is seeking U.S. approval of IPX-203, its extended-release carbidopa-levodopa (CD/LD) tablets, for Parkinson’s disease. The company submitted an Investigational New Drug Application to the Food and Drug Administration (FDA), which is based on top-line data from the Phase 3 RISE-PD clinical trial that showed IPX-203…
A dozen runners who live with Parkinson’s disease (PD) hope to heighten awareness of the neurodegenerative disorder and raise funds for research by taking on one of the nation’s most demanding relay road races — the Blue Ridge Relay — on Sept. 9-10. The 12 runners, who’ve dubbed themselves…
Screening a large database with machine learning tools helped scientists identify approved medicines for other diseases that reduced the risk of developing Parkinson’s, a study reported. According to researchers, these potential Parkinson’s disease therapies “deserve to be confirmed” in larger studies. “Drug repurposing or repositioning is the application of…
In-home, non-contact sensors that can identify changes in movement and behaviors may allow age-related diseases, including Parkinson’s, to be detected early, a study reports. By using machine learning tools, the study shows how outcomes such as fall risk, frailty, and cognitive abilities may be assessed in a home setting.
Mirapex (pramipexole) improved the quality of life for people with Parkinson’s disease compared to a placebo, according to a pooled analysis of several clinical trials. Quality of life improvements were seen regardless of disease stage, duration of treatment, or quality of life assessments before treatment. This analysis provided new…
In a webinar hosted by AC Immune, scientists discussed the various advantages of vaccines — ranging from their expected safety and long-lasting immune responses to potentially lower costs — in treating and possibly preventing Parkinson’s and Alzheimer’s disease. The “Key Opinion Leader” webinar, broadcasted on Aug.
Exercise can modify the connectivity of the brain’s pedunculopontine nucleus (PPN) with other areas of the brain in people with Parkinson’s disease and gait impairments, a study has found. Decreases in connectivity of the PPN on the left side of the brain after exercise were associated with motor improvements…
The University of Oxford Parkinson’s Disease Centre is working with Metabolon to identify metabolic biomarkers of Parkinson’s risk and progression that could lead to tailored disease treatments and better patient care. “Metabolon’s highly accurate data will enable the identification of metabolomic biomarkers crucial to understanding and better predicting…
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