News

Trial of Supplement Nicotinamide Riboside to Include Extension Study

An open-label extension study has been launched for NOPARK, a placebo-controlled Phase 2 clinical trial that’s assessing the effectiveness of nicotinamide riboside (NR) with Parkinson’s disease. NR is the active ingredient of Niagen, a dietary oral supplement that ChromaDex markets to promote “healthy aging.” Dietary supplements, unlike…

Eisai Expanding Research Into Parkinson’s Biomarkers, Treatments

Eisai is collaborating with Washington University School of Medicine in St. Louis in research into new treatments for Parkinson’s disease and other neurodegenerative disorders. The Japan-based pharmaceutical company’s aim is to meld the expertise of Washington University’s investigators in basic and clinical research for such disorders with its…

Incidence of Parkinson’s in US More Than Previously Estimated

Nearly 90,000 people, 65 or older, are diagnosed with Parkinson’s disease every year in the U.S., representing an increase of about 50% relative to previous estimates of the disease’s incidence, a study showed. “These updated estimates of incidence are necessary for understanding disease risk, planning health care delivery, and…

Gene Therapy SLS-004 Prevents Neurodegeneration In Mouse Model

SLS-004, Seelos Therapeutics‘ investigational gene therapy for Parkinson’s disease, lowered alpha-synuclein levels and prevented the degeneration of dopamine-producing, or dopaminergic, neurons in a mouse model of the disease, the company announced. A hallmark of the neurodegenerative disease, the loss of dopaminergic neurons in a brain region called the…

Trial of Mesdopetam for Levodopa-induced Dyskinesia Nears End

Top-line results are expected next month from a Phase 2b clinical trial testing whether the investigational oral therapy mesdopetam can ease levodopa-induced dyskinesia, or involuntary movements, in people with Parkinson’s disease. IRLAB Therapeutics, the therapy’s original developer and sponsor of the trial, announced that the final participant…