Better adherence to Mediterranean-style diets is associated with lower patient-reported symptom severity in people with Parkinson’s disease, according to a study of more than 1,000 patients. Between the two evaluated diets — the Mediterranean (MEDI) and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) — the MIND diet was…
Golexanolone, an investigational small molecule from Umecrine Cognition, reversed cognitive and motor symptoms in a rat model of Parkinson’s disease, in addition to easing signs of fatigue, anxiety, and depression. The experimental therapy is in clinical development for hepatic encephalopathy and primary biliary cholangitis, two conditions marked by…
People with Parkinson’s disease who are exposed to a high level of certain pesticides may see their motor and non-motor symptoms progress faster compared with those who are not as exposed, a U.S. study found. Among the 10 pesticides whose high exposure was found to be associated with faster…
A novel machine learning algorithm was able to accurately classify people with Parkinson’s disease based on their predicted rate of disease progression — slow, moderate, or fast — over the five years after diagnosis, a study using patient registry data reported. It also identified Parkinson’s motor symptoms as a…
Mortality rates appear to be lower among people with Parkinson’s disease psychosis (PDP) being treated with Nuplazid (pimavanserin) relative to those using other antipsychotic medications, according to a real-world study in the U.S. The study, “Mortality in Patients with Parkinson’s Disease-Related Psychosis Treated with Pimavanserin…
Blood levels of neuron-derived small vesicles containing alpha-synuclein and tau protein clumps — both linked to neurodegenerative disorders — can accurately distinguish between people with Parkinson’s disease and those with atypical parkinsonism, a study found. When isolated from the blood, these nerve cell vesicles may “provide a window…
Older adults with Parkinson’s disease who live in areas with more greenery, parks, or surface water are less likely to be hospitalized, according to an analysis of 16 years’ worth of U.S. data. The study, “Associations of Greenness, Parks, and Blue Space With Neurodegenerative Disease Hospitalizations…
The formation of toxic alpha-synuclein clumps may be the first and critical driver in developing Parkinson’s disease associated with mutations in the SNCA gene, according to a study looking at patient-derived neurons. While alpha-synuclein aggregation and abnormal calcium flow were detected at the earliest maturation stages of the specific…
Long-term exposure to air pollutants such as fine particulate matter (PM2.5), nitric dioxide, and black carbon increases the risk of dying from Parkinson’s disease, according to a study of more than 200,000 adults from six European countries. Notably, these associations were observed even for pollutant levels below current…
Throughout 2022, Parkinson’s News Today brought you daily coverage of the latest scientific breakthroughs and treatment advancements related to Parkinson’s disease. Here are the 10 most-read articles of 2022, with a brief description of what made them interesting and relevant to the Parkinson’s community. We look forward to continuing…
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