News

Supernus to Acquire Adamas and Its Therapies, Gocovri and Osmolex ER

Two established Parkinson’s disease (PD) treatments — Gocovri (amantadine) and Osmolex ER (amantadine hydrochloride) — will move to Supernus’ Pharmaceuticals when it completes an agreement now in place for it to acquire Adamas Pharmaceutical. The $450 million agreement — $50 million of which is contingent upon certain…

Extended Dosing Improves Safety of IkT-148009, Animal Studies Show

The safety profile of IkT-148009, an investigational oral medication for Parkinson’s disease, improved the longer the drug was dosed, demonstrating target selectivity, according to interim three-month animal data. The ongoing toxicology studies, conducted by the therapy’s developer, Inhibikase Therapeutics, were designed to meet regulatory requirements for regular…

MJFF Details Need for Diversity in Parkinson’s Research, Care

Current understanding of Parkinson’s disease does not reflect patients from diverse socioeconomic or ethnic backgrounds, and they remain poorly represented in research, according to a position paper from The Michael J. Fox Foundation for Parkinson’s Research (MJFF). “The current picture of PD [Parkinson’s disease] has been assembled from…

Immune Cells Found to Cooperate to Fight Toxic Protein Clumps

Immune cells in the brain responsible for breaking down the toxic protein clumps, or aggregates, that lead to nerve cell death in Parkinson’s disease join together to form networks to share the burden, a study showed for the first time. These networked cells also share energy-producing mitochondria to help…

GCase Enzyme Activity Not Linked to Parkinson’s Risk, Severity

The activity of the enzyme glucocerebrosidase, called GCase, is not tied to the risk of developing Parkinson’s, nor linked with the disease’s severity, a new analysis from Israel indicates. “We did not find an association with risk for” the early signs or symptoms of Parkinson’s disease, the researchers wrote,…