News

Enrollment is now complete in a Phase 3 trial assessing the safety and efficacy of solengepras (CVN424), Cerevance’s experimental non-dopaminergic therapy, in people with Parkinson’s disease. The Phase 3 ARISE trial (NCT06553027) is assessing solengepras’ efficacy, when given with levodopa and other standard Parkinson’s medications, in 341 patients with…

Vyalev, Abbvie‘s continuous under-the-skin infusion formulation of levodopa/carbidopa, reduces off time and eases motor and some nonmotor symptoms in adults with advanced Parkinson’s disease. That’s according to six-month data from an ongoing real-world study, ROSSINI (NCT06107426), which also showed the therapy improves patients’ quality of life. The…

The American Parkinson Disease Association (APDA) has launched a card game, called ParkinSex: The Game, to help people with Parkinson’s disease and their partners overcome challenges with physical and emotional intimacy that may be caused by the condition’s symptoms. The game can be ordered at the organization’s…

Chronic allergic diseases, including asthma and allergic rhinitis (hay fever), may increase the risk of developing Parkinson’s disease by contributing to persistent inflammation in the body, perhaps by maintaining elevated levels of immune cells in circulation, according to a large study from South Korea. While the mechanisms remain unclear,…

Scientists at Cedars-Sinai Health Sciences University are part of a team that will use a $9 million grant from the Aligning Science Across Parkinson’s (ASAP) initiative to study the connection between exposure to pesticides and air pollutants and the risk of developing Parkinson’s disease. The grant is part…

The Michael J. Fox Foundation for Parkinson’s Research (MJFF) changed the name of its large, observational study of Parkinson’s disease patients from the Parkinson’s Progression Markers Initiative (PPMI) to the Parkinson’s Precision Medicine Initiative, reflecting a major shift in Parkinson’s disease research. The foundation said the name change…

A specialized prebiotic supplement can restore healthy gut bacteria in people with Parkinson’s disease, and researchers have discovered a way to track this progress through a simple blood test. By measuring tiny particles in the blood that carry signals between the gut and the brain, scientists can now observe…

A woman diagnosed with early-onset Parkinson’s disease — later found to be caused by a mutation in the VPS13C gene — initially responded well to medication and deep brain stimulation (DBS), but then experienced rapid worsening of both her motor and nonmotor symptoms, ultimately leaving her unable to live…

By analyzing data sets from both humans and fruit flies and conducting experiments in living fruit flies, researchers have identified several genes that may be risk factors or useful therapeutic targets in Parkinson’s disease, according to a study. “We were particularly excited to find that manipulation of STAM1/2, INPP4A/B,…

The 2026 Parkinson’s Unity Walk raised almost $2 million, with more than 3,000 people participating in the 1.2-mile walk in New York’s Central Park on April 25, The Michael J. Fox Foundation (MJFF) said. An anonymous donor helped, matching every dollar raised up to $1.4 million. The…