Akineton (biperiden) is an anticholinergic agent used as an adjunct treatment for all forms of Parkinson’s disease (PD) to treat side effects such as involuntary movements caused by other medicines.

Anticholinergic agents have a variety of actions and clinical uses in different conditions. Their antisecretory activities decrease nasal and bronchial secretions, salivation, lacrimation, sweating and gastric acid production, and may be used to decrease secretions in allergic and inflammatory diseases. They also help relax smooth muscle in the gastrointestinal tract, bladder, and lungs, and are therefore used to treat gastrointestinal, urological or respiratory conditions associated with spasm and dysmotility. Some anticholinergics help prevent motion sickness and nausea and vomiting during surgeries.  They also help reverse neuromuscular blockers used during anesthesia and can be used to treat slow heart rhythm.

How Akineton works

Akineton works by helping to correct the chemical imbalance that is common in conditions such as PD. It is a weak peripheral anticholinergic agent, whose function is linked to the decrease or blockage of acetylcholine. Acetylcholine is a neurotransmitter that is found in the junctions between muscle cells and nerve cells as well as other sites of the central nervous system, carrying signals between cells.

PD is considered to be the result of an imbalance between the excitatory and inhibitory systems in the nervous system. Akineton competes with acetylcholine (called a competitive antagonism) at the excitatory system, restoring this imbalance.

Other details

The usual beginning dose of Akineton in PD is one 2 mg tablet three or four times a day, up to a maximum of eight tablets in 24 hours.

Akineton’s common side effects are agitation, blurred vision, constipation, dizziness or lightheadedness when sitting up or standing, drowsiness, dry mouth, nose or throat, nausea, nervousness, and/or upset stomach.

Note: Parkinson’s News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.