Most Parkinson’s Patients Show Non-movement Symptoms Like Depression, Sleep Problems, Survey Finds

Nearly all Parkinson’s disease patients experience non-movement symptoms, such as sleep disturbances or depression, which affect their quality of life as much as movement-related symptoms, according to an online survey of 700 participants, nearly 600 of whom completed it in full. Patients’ caregivers are those most likely to detect non-movement…

Nuplazid and Clozaril Are Most Reliable Parkinson’s Psychosis Therapies, Review Finds

The antipsychotics Nuplazid (pimavanserin) and Clozaril (clozapine) are the only therapies shown to improve Parkinson’s disease psychosis (PDP) symptoms without impairing motor function, in double-blind, placebo-controlled clinical trials, according to a review. The study, “Pharmacological interventions for psychosis in Parkinson’s disease patients,” was published in the journal Expert…

Study Reviews Use of Acadia’s Nuplazid as Treatment for Psychosis Linked to Parkinson’s Disease

Acadia Pharmaceuticals‘ Nuplazid (pimavanserin) is a reliable treatment to manage hallucinations and delusions associated with Parkinson’s disease psychosis (PDP), but its high cost and restricted access may limit its use in clinical practice, a new study says. The review, “Pimavanserin: A Novel Antipsychotic for Parkinson’s Disease Psychosis,”…

Suppressing Brain Immune Responses of Parkinson’s Patients Gives Promising Therapeutic Approach

Inhibitors of the JAK/STAT pathway may provide potential for treating patients with neurodegenerative diseases, particularly Parkinson’s, by reducing the degenerative inflammation in the brain according to the study “Inhibition of the JAK/STAT pathway protects against α-synuclein-induced neuroinflammation and dopaminergic neurodegeneration“, published May 4 in The…

FDA Advisory Committee Concludes Nuplazid Beneficial for Parkinson’s Disease Psychosis Treatment

ACADIA Pharmaceuticals accounced that the FDA Psychopharmacologic Drugs Advisory Committee voted that the benefits of Nuplazid (pimavanserin) for the treatment of Parkinson’s disease-related psychosis outweighed the risks of the drug. Nuplazid is a selective serotonin inverse agonist and, if approved, will establish a new and distinctly different pharmacological approach…