Estrogen, a female sex hormone, was found to enhance the neuroprotective effects of cytisine, a smoking cessation drug, in a female mouse model of Parkinson’s disease. That’s according to a study conducted by researchers at Texas A&M University, which analyzed the effects of cytisine in female mice that had…

Therapeutic nanocapsules designed to simultaneously increase dopamine levels and decrease neuroinflammation were able to improve motor and cognitive function in a mouse model of Parkinson’s disease, a study found. The scientists who developed the nanodrug, which was also engineered to have enhanced brain delivery, said they believe that simultaneously…

Pramipexole, the active ingredient in the Parkinson’s disease therapy Mirapex, appears to overactivate a brain region known as the external globus pallidus — findings that could explain the poor decision-making and impulse control that occurs as a side effect of the medication in some patients — according to…

Subcutaneous, or under-the-skin, injections of COYA 302, a combination therapy in development by Coya Therapeutics, were found to reduce excessive inflammation and immune cell activation in a mouse model of Parkinson’s disease. These beneficial effects were observed in the nigrostriatal pathway, a brain circuit responsible for motor control,…

Electroacupuncture reduced cellular hallmarks of Parkinson’s disease, including alpha-synuclein accumulation and nerve cell degeneration, in a mouse model of the disease. That’s according to the findings from a study that also found the treatment, a type of acupuncture where small needles inserted at specific points in the body are…

A once-daily treatment with GT-02287, an oral medication being developed by Gain Therapeutics, protected nerve cells from damage and rescued motor symptoms in a mouse model of Parkinson’s disease associated with mutations in the GBA gene. “We believe the data showing complete…

A ceramic blanket, a device being developed by Gladiator Therapeutics to improve blood flow and speed up wound healing, improved motor performance in a mouse model of Parkinson’s disease in a recent study. Besides improving balance and movement, the blanket also resulted in an increased number of cells…

Jotrol, Jupiter Neuroscience’s oral formulation of resveratrol, significantly improved muscle strength, motor coordination, and behavior in a mouse model of Parkinson’s disease, the company reported. “This research demonstrates the neuroprotectant abilities of Jotrol as a potential treatment to prevent onset and progression of PD [Parkinson’s] symptoms,” said Alison…

Treatment with stem cells engineered to produce a signaling protein called VEGF — which drives the growth of blood vessels — was found to lead to pain relief in a mouse model of Parkinson’s disease. Researchers say engineering stem cells for use in transplant “may potentiate the therapeutic efficacy”…

A team of researchers has designed nanoparticles able to restore the function of mitochondria — cells’ energy production centers — and improve motor behavior in a mouse model of Parkinson’s disease. Experiments in cell cultures revealed that the nanoparticles could restore function of reversibly damaged mitochondria and promote the…