News

People with Parkinson’s disease tend to report a poorer quality of life if their treatments cannot fully control nonmotor symptoms, which increase with disease duration and severity, a study reported. Findings highlight how important it is for clinicians to accurately identify and properly address nonmotor symptoms of Parkinson’s,…

Implanting electrodes into the brain triggers inflammation by activating a group of immune signaling proteins called the inflammasome — which detects infection and, in turn, prompts a strong inflammatory response, a new study shows. These findings may open new avenues to improve deep brain stimulation, a type of therapy used…

Sinopia Biosciences has selected SB-0110 as its lead clinical candidate for Parkinson’s disease after extensive preclinical studies. The move has triggered a cumulative funding of $3.3 million of its fast-track Small Business Innovation Research (SBIR) grant from the National Institute of Neurological Disorders and Stroke. The fast-track SBIR…

The first healthy volunteer has been dosed in a clinical study that will test the safety and efficacy of Herantis Pharma’s HER-096 treatment candidate for Parkinson’s disease, the company announced in a press release. The Phase 1a clinical trial also is evaluating the ability of HER-096 to penetrate…

Medications to prevent nausea and vomiting usually are not necessary for Parkinson’s disease patients beginning treatment with Kynmobi (apomorphine hydrochloride), according to a recent analysis of Phase 3 clinical trial data. Nearly 90% of patients who did not use these medications were still able to achieve an optimal…

Measuring the length and density of nerves in the cornea — the clear outer layer of the eyeball — can help distinguish between motor subtypes of Parkinson’s disease, a new study suggests. The study, “The severity of corneal nerve loss differentiates motor subtypes in patients with…

Greater proportions of immune regulatory B-cells were associated with better motor performance in people with early Parkinson’s disease, a study revealed. Regulatory B-cell subsets may be protective by limiting pro-inflammatory responses that contribute to disease progression, data showed. Meanwhile, elevated levels of antibodies produced by regular B-cells against the…

Remote assessments using smartphones and smartwatches could be used in clinical trials to track the severity of Parkinson’s disease, a new study indicates. “In this multicenter study, a commercially available smartwatch and a smartphone research application captured key motor and non-motor features of early, untreated” Parkinson’s, the researchers wrote,…

Changes in the electrical activity of a brain region called the left inferior frontal cortex (LIFC) may underlie certain speech difficulties in people with Parkinson’s disease, a study found. Patients with more severe articulation problems had higher frequency activity in the LIFC, and more limited communication between the LIFC…

A molecule associated with oxidative stress, called allantoin, is found at higher levels in the blood of people with Parkinson’s disease relative to their peers without the neurodegenerative disorder, according to a new study. Allantoin and its ratio to uric acid (UA) — the antioxidant molecule from which it’s…