Athira Pharma is completing its Phase 2 clinical trial of the experimental therapy fosgonimeton in people with Parkinson’s disease dementia or dementia with Lewy bodies with fewer participants than its initial target enrollment. According to a recent corporate update, the company has closed recruitment with 28 of…
Women who undergo surgery to remove both of their ovaries before age 43 have a five times higher risk of developing Parkinson’s disease in the future, according to a U.S. study. For younger women who had the procedure, called a bilateral oophorectomy, use of estrogen replacement therapy until the…
A Phase 2 clinical trial of Neuraly’s NLY01 failed to show the experimental therapy was superior to a placebo at significantly slowing motor symptom progression in adults with early and untreated Parkinson’s disease. Some promising trends among patients younger than 60 were seen following analyses of the trial’s…
NeuroRPM, an artificial intelligence (AI)-powered app designed to continuously monitor hallmark symptoms of Parkinson’s disease has been cleared for use by the U.S. Food and Drug Administration (FDA). “The clearance of NeuroRPM is a major milestone in the fight against Parkinson’s disease,” Alexander Ksendzovsky, MD, PhD, cofounder and chief…
While dopamine-replacing therapies are a key component of Parkinson’s disease care, they only reflect a person’s physical characteristics or the state of their disease. Adding a dose of “hopamine” — a person’s own unique set of hopes, desires, experiences, and skills — to Parkinson’s care takes patients’ personal characteristics…
Note: This story was updated March 24, 2023, to correct the name of CND Life Sciences. CND Life Sciences has signed a licensing and collaboration agreement with Beth Israel Deaconess Medical Center (BIDMC) in Boston to develop minimally invasive, diagnostic tests for Parkinson’s and other neurodegenerative diseases. The…
People with Parkinson’s disease have higher than normal levels of a nerve cell-damaging red/yellow pigment called pheomelanin in their substantia nigra, the area of the brain that’s mainly affected by the neurodegenerative disease, a study showed. By contrast, levels of eumelanin — an antioxidant black/brown pigment responsible for the…
Researchers at Michigan Technological University are developing a “smart” deep brain stimulation (DBS) system to treat Parkinson’s disease that’s automatically activated only when needed, making it more effective and energy-efficient. The researchers are using neuromorphic computing — an approach inspired by the structure and function of the human…
The U.S. Food and Drug Administration (FDA) has requested more information about the specialized pump used to administer ABBV-951 (foslevodopa/foscarbidopa), an under-the-skin formulation of levodopa/carbidopa, before it will consider approving the therapy for motor fluctuations in people with advanced Parkinson’s disease. The agency’s complete response letter comes 10…
Inflammatory biomarkers in the cerebrospinal fluid (CSF) of Parkinson’s disease patients with and without mutations in the GBA gene are at similar levels, and across all patients, higher levels of these markers associate with poorer cognition over time, a study found. TNF-alpha, a pro-inflammatory molecule, showed particular potential as a predictive…
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