UB-312, an experimental vaccine being developed for Parkinson’s disease by Vaxxinity, induced the production of antibodies targeting alpha-synuclein and slowed protein clumping in patients’ cerebrospinal fluid (CSF), the fluid that surrounds the brain and the spinal cord. The vaccine is designed to stimulate a patient’s immune system…
Toxic clumping of the alpha-synuclein protein, a hallmark of Parkinson’s disease, may lead to a calcium imbalance in which the mineral builds up to harmful levels in neurons early in the course of the neurodegenerative condition, according to a study in mouse and human cells. Single molecules of alpha-synuclein…
Compounds extracted from marigold flowers may be useful in treating Parkinson’s disease, according to a study done in laboratory models. The study, “Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson’s disease,” was published in Food…
Biopas Laboratories has asked the regulatory agencies of six countries in Latin America to approve Inbrija for Parkinson’s disease off periods, according to Acorda Therapeutics, the therapy’s developer and Biopas’ partner. Inbrija is a self-administered, inhaled levodopa therapy developed to reduce periods when motor symptoms are…
For people with Parkinson’s disease associated with mutations in the GBA gene, deep brain stimulation (DBS) may offer lasting motor benefits and help manage impulsive-compulsive behaviors, a study suggests. Despite experiencing faster cognitive decline following DBS when compared to patients with these mutations, most patients had not developed dementia…
Major problems with sensation in the airways — essential in preventing the dysphagia or swallowing difficulties that can lead to complications like aspiration pneumonia — were not observed between Parkinson’s disease patients and healthy adults in a small recent study. But given the proposed relationship between airway sensory impairments…
Surgical Information Sciences (SIS) has opened a clinical trial to evaluate whether its visualization technology system for locating brain structures can enhance the accuracy of implant placement during deep brain stimulation (DBS) surgery in people with Parkinson’s disease. Called VISION (NCT05774041), the observational and postmarketing study…
An ongoing and global Phase 3 clinical trial program for oral tavapadon, a selective dopamine receptor agonist aiming to improve motor function in people with Parkinson’s disease, expects to release study findings next year. Three separate, 27-week trials are evaluating tavapadon’s efficacy, safety, and tolerability against…
Swallowing problems can cause deadly complications for people with Parkinson’s disease, if not handled appropriately, making it critical that hospital clinicians partner with caregivers to help address the needs of patients. That’s the argument made by Annie Brooks, director of strategic initiatives at the Parkinson’s Foundation, in “Dysphagia…
Scientists in Thailand have developed lightweight gloves that help to lessen the tremors affecting daily life for people with Parkinson’s disease. The gloves currently are available at King Chulalongkorn Memorial Hospital in Bangkok, but the researchers plan to partner with entrepreneurs to further refine the devices. One goal is…
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