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Mouse study sheds light on alpha-synuclein buildup in the gut

Recent research in mice has revealed possible mechanisms by which alpha-synuclein protein is transported from blood cells in circulation to the gastrointestinal (GI) tract, where the protein is then thought to travel to the brain to drive Parkinson’s disease. Cellular carriers called extracellular vesicles (EVs) released from red blood…

Wrist-worn device shows good accuracy for measuring off time

The Parkinson KinetiGraph (PKG), a wrist-worn device resembling a watch, offers a moderate level of measurement for tracking symptom fluctuations and medication side effects in individuals with Parkinson’s disease. That’s according to the study “Application of single wrist-wearable accelerometry for objective motor diary assessment in…

Activating select estrogen receptor shows promise in lab models

Treatment with cianidanol, a plant molecule that can activate a specific estrogen receptor in the brain, showed neuroprotective potential in cell and animal models of Parkinson’s disease, a study reports. “The identification of cianidanol as a selective estrogen receptor beta agonist and evaluation of its neuroprotective…