A mathematical model created to more effectively prevent protein clumping, widely thought to underlie diseases like Parkinson’s, found that different potential treatments work best at different disease stages. As such, this model may help in designing and timing the use of therapies against protein aggregates, and in testing them in…
Mutations in the SNCA and CTSB genes — among the many known to increase the likelihood of Parkinson’s disease — also contribute to the risk associated with mutations in the GBA gene, one of this disease’s most common and significant genetic risk factors, a study shows. Its results further…
Online forums have markedly altered how patients, caregivers, and healthcare professionals communicate and connect. Even when miles apart, individuals can establish supportive relationships, share experiences and information, and sometimes simply vent. Bionews Services, a leading online health, science and research publication company, has been rolling out its…
Deep brain stimulation (DBS) eases tremors and muscle rigidity, and improves cognition and mood in Parkinson’s patients by raising dopamine levels in the brain, a small study from Johns Hopkins Medicine suggests. The research, “Effect of STN DBS on vesicular monoamine transporter 2 and glucose metabolism…
PDGENEration, a new program offered through the Parkinson’s Foundation, will provide free genetic testing for people with Parkinson’s disease. Around 15% of Parkinson’s cases are thought to involve a significant genetic component — but genetic testing for the disease has not been common. “Mutations in several…
A review by the U.S. Food and Drug Administration (FDA) found that Parkinson’s patients treated with medications containing entacapone are at no increased risk of prostate cancer. As such, the agency stands by its current recommendations for the use of Stalevo (entacapone/carbidopa/levodopa) and Comtan (entacapone; brand name is Comtess…
A compound found in extra virgin olive oil may have beneficial effects in Parkinson’s disease, a study in the nematode worm Caenorhabditis elegans shows. Researchers say the compound Tyrosol reduced oxidative stress and induced the expression of different protective genes in a model of Parkinsonism. Titled “…
High levels of corticosterone — a hormone that regulates energy, immune, and stress responses — is a risk factor for the development and progression of Parkinson’s disease, according to a mouse study. The study, “Chronic corticosterone aggravates behavioural and neuronal symptomatology in a mouse model of alpha-synuclein…
Drinking coffee may reduce tremors in Parkinson’s disease patients, but only among men, a recent study suggests. The study, “Sex-dependent Effects of Coffee Consumption on Newly Diagnosed Parkinson’s Disease,” was published recently in the journal BMC Neurology. There is some evidence that drinking coffee reduces the risk…
The experimental gene therapy AXO-Lenti-PD (OXB-102) was seen to be both safe and effective in a primate model of Parkinson’s disease, a study reported, supporting a clinical trial getting underway in patients. The findings were published in the journal Molecular Therapy Methods & Clinical Development in the paper, “…
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