News

A proposed system for classifying subtypes of Parkinson’s disease is strongly linked to disease duration and severity, a new study found. This suggests that the system’s proposed subtypes might actually reflect different stages of the disease, rather than distinct clinical subtypes. The study, “The role of disease…

Anavex Life Sciences announced plans to continue to screen and enroll patients into its active trials for Alzheimer’s disease and Rett syndrome, in accordance to institutional rules and government guidance related to the COVID-19 pandemic. A Phase 2 study of people with dementia linked to Parkinson’s disease is fully…

Despite being safe and well-tolerated, foliglurax (PTX002331), an investigational therapy for Parkinson’s disease, failed to significantly reduce some of the effects associated with long-term use of levodopa, including its “wearing-off” effect and motor complications, according to data from a Phase 2 clinical trial. As a result,…

Theranexus’ lead candidate THN102 significantly lowers excessive daytime sleepiness in people with Parkinson’s disease, according to final data from a Phase 2 clinical trial. “The symptom addressed by THN102 … affects around 40% of patients. It is particularly debilitating and represents one of the primary risk factors…

Long-term use of blood pressure medication Dynacirc (isradipine) does not slow disease progression in people with early Parkinson’s disease, according to findings from a Phase 3 clinical trial. These results contrast with what was previously observed in mice, in which the medication eased damage to dopaminergic…

Genetic differences influence the physical properties of the brain’s cerebral cortex and likely play a key role in cognition and risk of neurological conditions, including Parkinson’s disease, a new study has found. Titled “The genetic architecture of the human cerebral cortex,” the study was published in the…

The Brian Grant Foundation (BGF) has opened a new online education program that seeks to help exercise professionals provide safe and effective classes for Parkinson’s disease (PD) patients. Called Grant’s Army, the program features a compilation of cutting-edge PD exercise research, case studies of exercise programs…

Genetic elements that are able to “copy and paste” themselves into different sections of DNA help to control the development of neurons, a new study suggests. Understanding this process could have important implications for designing therapies for neurological conditions such as Parkinson’s disease. The study, “Transdifferentiation of…

Researchers have developed a way to closely study the function of a cell’s transportation network, made up of structures called microtubules, that appears to be impaired in people with Parkinson’s disease. This technique, called “microstretcher,” may help to better understand microtubules’ deficits and their underlying causes in Parkinson’s,…

An oxygen-free (anaerobic) formulation of dopamine infused directly into the brain of monkeys with induced Parkinson’s safely improved both their motor and cognitive symptoms, according to a new study. These findings support a proof-of-concept clinical trial of this treatment approach, adapted to people with the disease.