Constipation and sleep behavior disorder are strongly associated with future decline in some cognitive measures in people — especially men — newly diagnosed with Parkinson’s disease, a study suggested. Its researchers recommend early assessment of sleep disorders and constipation to help predict cognitive changes in later disease stages. …
A rare neurodegenerative disorder called neuronal intranuclear inclusion body disease (NIID) may share a similar genetic mutation with Parkinson’s disease (PD), a study suggests. Patients who present with typical Parkinson’s disease may carry this mutation, respond to parkinsonian medications and not develop clinical features of NIID. The study, “Association…
Anavex 2-73 (blarcamesine) safely led to significant improvements in several aspects of cognition, including choice reaction time and episodic memory, in people with Parkinson’s disease dementia (PDD), new data from a Phase 2 trial report. According to Anavex Life Sciences, the therapy’s developer, these findings from…
A fully automated process for growing three-dimensional (3D) midbrain-like organoids — a “mini-organ” model of the brain — has opened the door for the simultaneous testing of thousands of new potential Parkinson’s disease treatments. The midbrain, the topmost part of the brainstem, contains approximately 75% of…
A Phase 1 clinical trial evaluating umbilical cord-derived mesenchymal stem cells (MSCs) as a potential treatment of bradykinesia — slowness or difficulty with movement — in people with Parkinson’s disease is expected to soon open in the U.S. Recruitment is expected to go well, and dosing of a first patient…
Most people with Parkinson’s disease have positive attitudes about telemedicine during the COVID-19 pandemic, a small Japanese study reveals. The study, “Attitudes towards telemedicine of patients with Parkinson’s disease during the COVID‐19 pandemic,” was published in Neurology and Clinical Neuroscience. It was funded by…
A computational model of how Parkinson’s disease evolves over time may help guide physicians in tailoring levodopa doses to a patient’s needs at given disease stages. Levodopa works to ease the slowness or difficulty in moving, known as bradykinesia, experienced by many people with Parkinson’s. But its effectiveness…
The Brain Mind Institute has joined with Idorsia Pharmaceuticals in a three-year effort to discover and develop new therapies for Parkinson’s disease and other neurodegenerative disorders. “This collaboration combines some of the best skills and know-how from academia and industry with the common objective of finding new small molecules…
A new wearable device could enable monitoring of motor symptoms as well as electrical activity of the brain, heart, and muscles in people with Parkinson’s disease. The device was described in the journal Sensors, in the study “A Multi-Sensor Wearable System for the Quantitative Assessment of…
Parkin protein deficiency — which is associated with early onset Parkinson’s disease — is only detrimental when dopamine-producing neurons undergo a metabolic switch as they mature, a new study reported. Under such conditions, nerve cells lacking in parkin cannot effectively recycle damaged mitochondria (the cells’ powerhouses, or energy sources), significantly…
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