Clusters of Parkinson’s disease correlated significantly with air quality in urban versus more rural areas, a study spanning the Geneva canton of Switzerland reports, lending support to the idea that air pollution contributes to the disorder. The study, “Geospatial analysis of individual-based Parkinson’s disease data supports…
Alterations in gut microorganisms found in the appendix of people with Parkinson’s disease were associated with elevated digestive bile acids that may play a role in disease development, a study has revealed. The discovery suggests targeting microbial-derived bile acids as a…
Note: This story was updated Feb. 9, 2021, to clarify details surrounding the grant Chronic Care Collaborative received from Adira. Greg Smiley’s world changed abruptly in 2013. He was racing down a mountain road on an outback cycling trip in South Africa, when he hit an obstruction in the road…
Some medications currently used to treat enlarged prostate, such as alpha-1 adrenergic receptor antagonists — called alpha-blockers — might lower the risk of Parkinson’s disease, according to a new study. While more research is needed to fully determine a causal effect of alpha-blockers in treating the neurodegenerative disease, scientists…
Scientists at Cognition Therapeutics have found that compounds that are able to dampen the activity of sigma-2 receptors — receptors that are part of a network that controls the destruction of misfolded proteins — are highly effective at preventing molecule trafficking defects driven by the presence of misfolded alpha-synuclein inside…
Neurocrine Biosciences announced that it is stopping its work with Voyager Therapeutics to further develop VY-AADC (NBIb-1817) as a potential one-time gene therapy for Parkinson’s disease. The therapy, by Voyager and being advanced with Neurocrine’s support, is in a Phase 2 clinical trial (…
Due to negative clinical trial findings, Biogen has discontinued the development of cinpanemab (BIIB054), an investigational medication intended to treat Parkinson’s disease, the company announced in its 2020 investors report. Cinpanemab is a human-derived antibody that targets alpha-synuclein, thought to be one of the key hallmarks of Parkinson’s disease. In the…
Scientists have developed a new method of noninvasive electrical stimulation that can suppress tremors in people with essential tremor syndrome by interfering with the abnormal brain waves that trigger them. According to the research team, if proven effective in larger studies this new method may be adopted as a way…
Prolonged, low-level inhalation of the common weed-killer paraquat, implicated in the risk of Parkinson’s disease, caused male mice to lose at least some of their sense of smell, a study reports. This work also supported previous studies showing the inhaled chemical enters the brain via the olfactory nerve.
A scientist at the University of Latvia claimed a journal’s Young Investigator Award for her research showing how small vesicles derived from stem cells could lessen motor symptoms in a rat model of Parkinson’s disease. Karīna Narbute’s work establishes a proof of concept for the potential of small vesicles —…
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