PINK1 and Parkin — two proteins whose deficiency has been linked to early-onset Parkinson’s — are involved in the degradation and recycling of mitochondria in neurons, a study shows. While these proteins were known to contribute to mitochondrial recycling in other cell types, this study provides a closer look into mitochondria’s…
The Parkinson’s Foundation announced it will invest $4.3 million in 29 grants for projects that will investigate the underlying causes of Parkinson’s disease and its biological mechanisms, with the goal of finding new treatments. This investment is in addition to the $10 million the Foundation committed to spend earlier this year. “The…
Due in large part to a $15 million Norton Healthcare Foundation investment, the Norton Neuroscience Institute (NNI) has expanded to offer state-of-the-art technologies and enhanced amenities for people with Parkinson’s and other neurological diseases. The newly opened center at the Louisville, Kentucky-based nonprofit institute, which serves its regional community,…
An almost €2 million (about $2.3 million) EU-funded project is advancing the understanding of how damaged or abnormal cell parts are removed at the synapses, a process known as synapse-specific autophagy, and how defects in this mechanism contribute to neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s. Synapses,…
Among people with Parkinson’s disease, those with low blood levels of uric acid — a natural antioxidant — tend to have more severe non-motor symptoms like anxiety, depression, and cognitive dysfunction, a study indicates. It also showed a link between uric acid levels and gray matter volume in the…
Lower levels of dopamine transporter protein in the striatum — a brain region affected significantly in Parkinson’s — may predict the development of the neurodegenerative disease up to eight years earlier in older adults carrying the most common genetic risk factor, a small study suggests. However, the observed variability…
A non-invasive test that measures signals from the olfactory bulb — the part of the brain responsible for scent-perception — may aid in the early diagnosis of Parkinson’s disease, according to a recent study. The test, called an electrobulbogram, also also can inform about disease duration, severity, and the…
Electrical stimulation given through the scalp to a brain region called the supplementary motor area may ease certain aspects of upper limb bradykinesia in people with Parkinson’s disease, a small study suggests. The study, “Transcranial direct current stimulation of supplementary motor area improves upper limb kinematics…
A medicine approved to treat attention deficit hyperactivity disorder (ADHD), called atomoxetine, could help to improve thinking and impulse control in certain people with Parkinson’s disease, a small study suggests. Patients with the greatest loss of integrity in a part of the brainstem called locus coeruleus, evident on a brain scan,…
Telehealth, together with wearable sensors that accurately monitor symptoms like tremor, may help to improve quality of life for people with Parkinson’s disease, a small, single-center study suggests. Patients in the study also expressed comfort with online health checkups and the sensory device used, but many still preferred in-person care.
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