A gene therapy targeting the substantia nigra, the brain region with dopamine-producing nerve cells, may boost the benefits of levodopa for people with Parkinson’s disease, a study reports. This idea was tested in a new mouse disease model — one in which Parkinson’s symptoms appeared after disrupting a protein…
By lessening the involuntary movements, called dyskinesia, experienced by people with advanced Parkinson’s disease, treatment with AbbVie’s Duodopa (levodopa-carbidopa intestinal gel) was linked with better health-related quality of life, according to a post-hoc analysis of a clinical trial. Duodopa treatment also was tied to other added benefits, namely…
A new, potent inhibitor of the Bach1 protein — whose levels are elevated in brain tissue of Parkinson’s disease patients — showed neuroprotective effects in lab tests and lessened symptoms in a mouse model of acute Parkinson’s, a study found. Most importantly, the inhibitor had therapeutic potential when administered…
ABBV-0805, AbbVie’s experimental antibody-based therapy for Parkinson’s disease, selectively binds to toxic clumps of the alpha-synuclein protein — a hallmark of the disease — preventing their spread and prolonging survival in mouse models of Parkinson’s, a study shows. Also, the investigational antibody was found to bind to harmful…
Treatment with the investigational therapy CST-103 increased blood flow to certain regions of the brains of people with Parkinson’s disease and mild cognitive impairment, results of a small clinical trial show. The type of increased blood flow that was seen “correlates with increased neuronal activity and cognitive benefit,” Gabriel…
An investigational therapy, ATH434 was able to reverse some gastrointestinal problems in a mouse model of Parkinson’s disease, according to its developer Alterity Therapeutics. “Practicing clinicians are well aware of the substantial impact that these symptoms have on the quality of life of individuals with Parkinson’s disease,” David Stamler,…
The active agent in Solace PS128, a probiotic sold by Oryx Biomedical, eased disease symptoms and improved life quality in 25 people with Parkinson’s disease given the supplement in a small, open-label clinical trial. “Solace PS128 is the result of more than 20 years of scientific research,” David…
Scientists from Northwestern University will use two grants — totaling $17.9 million — from the Aligning Science Across Parkinson’s (ASAP) initiative to study alterations in the brain that contribute to the development of Parkinson’s disease. Their research focuses on brain circuits, the specific populations of interconnected brain cells…
The death rate from Parkinson’s disease in the U.S. has gradually and significantly increased — by 63% — over two decades across all age groups, sexes, and racial and ethnic groups, according to a study based on nationwide mortality data. In the same period, men died twice as much…
A team of scientists from the University of Florida (UF) will use a $1.1 million grant to further their work on the use of artificial intelligence- or AI-powered medical research for predicting and diagnosing Parkinson’s disease while maintaining patient privacy. This grant, from the National Institutes for Health (NIH),…
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