News

Targeting a brain network that links thinking and movement may be an effective treatment strategy for easing motor symptoms in people with Parkinson’s disease. The somato-cognitive action network (SCAN) lies within the motor cortex, a brain region that controls body movements. In Parkinson’s, SCAN dysfunction, particularly increased connectivity between…

The University of Southern California’s Keck School of Medicine is recruiting patients for a Phase 1 clinical trial evaluating RNDP-001, an experimental cell replacement therapy being developed by Kenai Therapeutics for moderate to severe Parkinson’s disease. The company-sponsored REPLACE (NCT07106021), which began dosing late last year,…

Merz Therapeutics North America has launched “Celebrating the Fighters,” a nationwide U.S. community campaign honoring the resiliency and courage of people with Parkinson’s disease. The campaign features several initiatives, including a national TV ad, and offers social media and advocacy resources. It leverages the resilience and spirit of…

Parkinson’s disease may actually begin deep in the gut, where immune cells meant to protect the body inadvertently help toxic proteins make their way to the brain, according to a new study. Researchers at the UK Dementia Research Institute at University College London (UCL) have identified a specific type…

Small particles called exosomes may help deliver curcumin directly to dopamine-producing nerve cells damaged in Parkinson’s disease, a study in rats suggests. In laboratory and animal experiments, the targeted delivery helped protect these cells and was associated with improved outcomes, pointing to a potential precision-delivery strategy for future research.

Boston University has been awarded a $2 million research grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to support a clinical study examining motor and cognitive factors related to changes in walking among people with Parkinson’s disease who use MedRhythms’ music-based platform, MOVIVE. MOVIVE…

Researchers at Case Western Reserve University in Cleveland, Ohio, developed a new compound that blocks a harmful interaction between the alpha-synuclein protein and a mitochondrial enzyme called ClpP. In a mouse model of Parkinson’s disease, the treatment helped preserve dopamine-producing brain cells and improved movement and cognitive performance. The…

In the Netherlands, new cases of Parkinson’s disease occur more often in men, older adults, people with higher socioeconomic status, and residents of the northern provinces, suggesting that long-term environmental factors may contribute to the disease, according to a study from Utrecht University. According to a university press…

Mair Therapeutics is collaborating with Radboud University in the Netherlands to advance Parkinson’s disease research by developing small molecules designed to target TMEM175, a protein that genetic studies have linked to Parkinson’s risk. “Parkinson’s disease remains one of the most pressing medical challenges of our time,” Vasily Kazey, PhD,…

Michael J. Fox is returning to the small screen for season three of Apple TV+’s “Shrinking.” Once again, he is using his craft to elevate awareness and understanding of Parkinson’s disease. For the actor and advocate, the role is a continuation of a mission that has shaped his life…