In a new approach to drug discovery, seven molecules, or “hits,” that may treat familial Parkinson’s disease were identified in the first open science competition run by the Canadian nonprofit Conscience. Launched with support from the global public-private partnership Structural Genomics Consortium (SGC) and a grant from…
Shingles, an infectious disease marked by a painful skin rash with blisters, wasn’t associated with an increased risk of Parkinson’s disease, according to a study of more than 1 million U.S. veterans. “We showed no evidence of an increased risk of incident [Parkinson’s disease] after [shingles] in a large,…
Reduced activity of the RIT2 gene in a subtype of nerve cells — regardless of  whether they produce dopamine — may be implicated in the development of Parkinson’s disease, according to a study that measured gene activity in more than 300,000 individual brain cells. The protein encoded by RIT2…
The RAZ Memory Cell Phone will allow people with impaired speech, including those with Parkinson’s disease, to speak using their own voice during video phone calls and be fully understood. The speech recognition technology was developed by Voiceitt, a voice AI and machine learning company, in partnership…
Phosphorylated alpha-synuclein, a modified form of the protein that forms toxic clumps in the brains of people with Parkinson’s disease and related disorders, appears to play an important role in the normal function of nerve cells, a study shows. When it’s modified, alpha-synuclein binds…
Exposure to nanoplastics, micro-sized fragments of plastic waste found in the environment, mimicked the signs and symptoms of Parkinson’s disease in tiny worms and in human nerve cells in the lab, a study reported. Low concentrations of nanoplastics were found to penetrate the walls of the worms’ intestines and…
One year of continuous subcutaneous (under-the-skin) apomorphine infusion (CSAI) reduced the severity of advanced Parkinson’s disease among patients across India, a study showed. Disease motor symptoms, as well as various Parkinson’s nonmotor symptoms like fatigue, pain, anxiety and depression, — along with quality of life — improved…
People with Parkinson’s disease and their caregivers need more timely information on what palliative care services are available and how to access them, along with more of such services, according to a review of published studies. Palliative care refers to specialized medical care for people living with a serious…
Alterity Therapeutics‘ ATH434 improved motor performance and overall function in non-human primates with induced Parkinson’s disease, according to data presented at the recent Future of Parkinson’s Disease Conference 2023. The investigational therapy is currently undergoing evaluation in an open-label biomarker study called ATH434-202 (NCT05864365), which has…
Altered levels of proteins in the amygdala, the brain region involved in memory, decision-making, and emotional responses, were discovered in Parkinson’s disease patients, a study reports. These changes in the amygdala were associated with synapses, the minute gaps between nerve cells through which impulses pass, allowing the cells to…
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