Gain Therapeutics’ GT-02287, an oral candidate therapy for Parkinson’s disease, led to dose-dependent improvements in the health of nerve cells and fine motor skills in mice. These findings, presented recently as a poster at the International Congress of Parkinson’s Disease and Movement Disorders 2022 in Madrid, add to…
Using a newly created probe and non-invasive PET scans, researchers were able to visualize sites of alpha-synuclein protein clumps — associated with nerve damage in Parkinson’s disease — in the brains of living patients, scientists reported. This method may help in diagnosing conditions related to alpha-synuclein clumping, referred to…
Screening a large database with machine learning tools helped scientists identify approved medicines for other diseases that reduced the risk of developing Parkinson’s, a study reported. According to researchers, these potential Parkinson’s disease therapies “deserve to be confirmed” in larger studies. “Drug repurposing or repositioning is the application of…
In-home, non-contact sensors that can identify changes in movement and behaviors may allow age-related diseases, including Parkinson’s, to be detected early, a study reports. By using machine learning tools, the study shows how outcomes such as fall risk, frailty, and cognitive abilities may be assessed in a home setting.
Mirapex (pramipexole) improved the quality of life for people with Parkinson’s disease compared to a placebo, according to a pooled analysis of several clinical trials. Quality of life improvements were seen regardless of disease stage, duration of treatment, or quality of life assessments before treatment. This analysis provided new…
Older age at disease onset is associated with greater motor and nonmotor impairment in people with idiopathic Parkinson’s disease, according to a study by scientists in Luxembourg. Nonmotor symptoms such as urinary incontinence and apathy in those diagnosed at older ages were found to be mainly driven by the natural…
More disability and higher levels of depression in Parkinson’s disease patients predicted an increase in burden and depression of their care partners, such as family and friends, over two years, a study concluded. The findings underscore the need to monitor the burden of care partners over time. Treatment targeting disease severity,…
The cognitive exercise smartphone app NeuroNation, which combines personalized tasks and gamification, is useful and feasible for adults with mild Parkinson’s disease, a pilot study concluded. The researchers noted the app was a success in terms of the patients’ perception of its usability and in achieving cognitive improvements,…
Enhanced ultrasound signals in the substantia nigra, the area of the brain impacted by Parkinson’s disease, are associated with increased motor disability and gait disturbances, a study concluded. The researchers noted that these ultrasound signals, called hyperechogenicity, may be useful a biomarker that reflects disease severity. “Our results may…
The change in motor symptoms after deep brain stimulation (DBS) in people with Parkinson’s disease did not differ regardless of whether microelectrode recording was used during their surgery to guide electrode placement, a pooled analysis of published studies suggest. However, the analysis found that a reduction in the…
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