Helping Nerve Cells Clear Damaged Mitochondria May Treat Parkinson’s, Study Finds
Parkin protein deficiency — which is associated with early onset Parkinson’s disease — is only detrimental when dopamine-producing neurons…
Articles by Marta Figueiredo, PhD
First Patients Dosed in Phase 3 Trials Testing Tavapadon in Parkinson’s Patients
The first patients have been dosed in three Phase 3 clinical trials evaluating the safety and effectiveness of tavapadon,…
Common Parkinson’s Mutation Tied to Neuron Damage via Calcium Imbalance in Study
The most common mutation associated with Parkinson’s disease — called LRRK2-G2019S — results in abnormal global protein production that…
Prevalent Form of Gut Hormone May Be Linked to Dementia in Parkinson’s
Higher levels of unacylated-ghrelin, the most prevalent form of ghrelin (acyl-ghrelin) — a gut hormone with neuroprotective properties — suppress…
Phase 2b Trial of Prasinezumab in Patients With Early Parkinson’s Expected by 2021
Roche, in partnership with Prothena, will launch a Phase 2b clinical trial to evaluate the effectiveness of prasinezumab (…
Chemical-electrical Brain Signals Link More Complex Than Thought, Study Finds
The association between dopamine levels and electric brain signals called beta waves — thought to be of an opposite…
Neurons Adapt Metabolism to Resist Mitochondria-associated Neurodegeneration in Mice
In the presence of mitochondrial dysfunction, nerve cells (neurons) switch to an alternative metabolic program to resist neurodegeneration, according to…
Possible Causes of Sensory Nerve Damage, Pain in Parkinson’s Identified
The levels of two types of fatty molecules — anandamide and glucocerebroside — are significantly altered in people…
Dietary Silicon-based Antioxidant Agent Prevents Parkinson’s in Mouse Study
A new dietary silicon-based antioxidant agent prevented neurodegeneration, and motor balance and coordination problems, in a mouse model of…
Late-stage Patients Show Benefit with Deep Brain Stimulation, Small Study Finds
Most people with late-stage Parkinson’s disease showed benefit from continued treatment with subthalamic deep brain stimulation (STN-DBS) in a…