A Day in the Life of Dr. C’s Parkinson’s Self-management

If a casual observer were to take a snapshot of my life, they would see a gray-haired guy sitting down while his partner scurries about doing house chores and computer work. But looks can be deceiving because I am using my Parkinson’s self-management toolkit. My past work designing rehab…

Man-made DNA Molecules May Help Prevent Parkinson’s, Study Finds

Osaka University scientists have built short fragments of DNA that can stop the production of abnormal alpha-synuclein protein in the brain — which may advance the development of new therapies for the control and prevention of Parkinson’s disease. The study, “Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting…

PF-360 Provides Some Benefits But Does Not Improve Dopaminergic Function, Mouse Study Shows

Treatment with PF-360, an investigational leucine-rich repeat kinase 2 (LRRK2) inhibitor, can efficiently decrease LRRK2’s phosphorylation levels, known to be elevated in Parkinson’s patients, in the brains of a mouse model of Parkinson’s disease, a preclinical study reports. However, despite some observed dose-dependent therapeutic effects, including gait improvement, no robust changes…

Communication Deficits in Parkinson’s Patients Caused by Motor and/or Cognitive Impairment

Communication difficulties are caused by motor and/or cognitive impairment in people with Parkinson’s disease, a review study highlights. An interdisciplinary approach to assess changes in patients’ daily communications may help detect and monitor motor and cognitive symptoms in this population. The review, “Communication impairment in Parkinson’s disease: Impact…