LUMA trial expands to patients with LRRK2 gene mutation

The Phase 2 LUMA clinical trial, which is testing the experimental LRRK2 inhibitor BIIB122 in people with Parkinson’s disease, is expanding to open enrollment of patients who have a mutation in the LRRK2 gene, in addition to patients without mutations. Meanwhile, the Phase 3 LIGHTHOUSE study, which had been…

Dosing Begins in Phase 2b Study of Oral BIIB122/DNL151

A Phase 2b clinical trial evaluating the investigational oral therapy BIIB122/DNL151 for the treatment of people with Parkinson’s disease has started dosing patients. The LUMA study (NCT05348785), led by Biogen in collaboration with Denali Therapeutics, is one of two late-stage trials planned for this year to further evaluate BIIB122/DNL151…