A Phase 1/2a clinical trial evaluating TED-A9, a human stem cell-based therapy, in people with Parkinson’s disease has finished dosing with no safety concerns identified to date. The therapy, delivered as a cell transplant directly into the brain, was given successfully to 12 adults diagnosed with Parkinson’s…
The selective loss of dopamine-producing nerve cells in one side of the brain of mice, to mimic Parkinson’s disease, impacted the length of movement sequences on the opposite side of the body, but not the same side, a study shows. The study’s researchers discovered two distinct populations of these…
Toxic clumps of the protein alpha-synuclein change the way the brain cells most affected by Parkinson’s disease utilize energy, a study shows. Its researchers wanted a clearer understanding of how “key metabolic processes” are affected by the protein’s aggregation, damaging “vulnerable” nerve cells within the brain, they wrote. To…
A grant from the Michael J. Fox Foundation (MJFF) will help Clene Nanomedicine to advance in development CNM-Au8, its cellular energy-promoting, investigational Parkinson’s treatment. The grant will help to support preclinical studies in patients’ nerve cells and mouse models of the disease, as well as facilitate the launch of a Phase 2 safety and effectiveness…
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