Wearable sensors that monitor motor symptoms like tremor can accurately assess eligibility of Parkinson’s disease patients for apomorphine pump therapy, aligning closely with traditional clinical evaluations, according to a study. The findings suggest that wearable sensors have “the potential to revolutionize the way patients are assessed and treated, ultimately…

Serina Therapeutics has partnered with Enable Injections to advance SER-252 (POZ-apomorphine), Serina’s lead treatment candidate for advanced Parkinson’s disease, in combination with the enFuse wearable delivery system. EnFuse is designed to allow patients to self-administer SER-252 subcutaneously (under the skin) in a faster, simpler, and more…

An oral spray was safe and efficient at delivering apomorphine to people with Parkinson’s disease, a study found. A subcutaneous injection formulation of apomorphine, sold as Apokyn, is approved in the U.S. to treat off episodes — periods in which symptoms return between doses of levodopa treatment — in…

One year of continuous subcutaneous (under-the-skin) apomorphine infusion (CSAI) reduced the severity of advanced Parkinson’s disease among patients across India, a study showed. Disease motor symptoms, as well as various Parkinson’s nonmotor symptoms like fatigue, pain, anxiety and depression, — along with quality of life — improved…

An extract from the plant Tabebuia impetiginosa, which has been used for centuries in traditional medicines of South America, eased Parkinson’s disease symptoms in rat models, a study reported. Treatment aided the animals’ locomotion, eased evident stiffness, and raised dopamine levels in brain tissue, its researchers wrote. The study, “…

Supernus Pharmaceuticals has submitted a new drug application to the U.S. Food and Drug Administration (FDA) seeking approval of SPN-830, its apomorphine infusion pump, the company said. If approved, the pump will be used for the continuous treatment of on-off episodes in adults with Parkinson’s…

A clinical study will test the potential of a specific magnetic resonance imaging (MRI) technique to diagnose Parkinson’s disease at early stages. The 18-month project, supported by a grant from the Center for Clinical and Translational Science in the U.K., will take place at the University…

The U.S. Food and Drug Administration has accepted Sunovion‘s resubmitted new drug application (NDA) for APL-130277, an oral apomorphine therapy for treating off episodes in Parkinson’s disease. The FDA had asked for additional information regarding APL-130277, following the first NDA in mid-2018. A…

Sunovion Pharmaceuticals has re-submitted a new drug application (NDA) to the U.S. Food and Drug Administration (FDA), once again seeking the approval of its below-the-tongue formulation of apomorphine — called APL-130277 — for Parkinson’s off periods. The re-submission is a follow-up to the FDA’s “complete response…

Under-the-skin infusions of low-dose apomorphine using a wearable device called h-Patch may help in avoiding off periods and improving motor function in Parkinson’s patients, Valeritas, the technology’s developer, reports. A preclinical study found that apomorphine delivered using h-Patch could be detected in the blood within two hours, with a…