Among Parkinson’s patients, those carrying GBA and APOE gene mutations have a significantly faster cognitive decline and a higher risk of progression to dementia, a study in more than 1,000 patients across Northern Europe reported. Notably, the dementia risk was even higher when mutations in both genes were present. No significant associations…
Exercise can slow early cognitive decline in Parkinson’s disease patients who have a variant of the APOE gene, called APOE4, a recent study has found. “Additional research is needed to confirm our findings, but these results would support the use…
Five genes appear to be involved in the onset and development of Lewy body dementia (LBD), a neurodegenerative disorder characterized by toxic protein clumps, known as Lewy bodies, inside brain cells, a study by a branch of the National Institutes of Health reported. Some of these genes are also associated…
A variant of the apolipoprotein (APOE) protein, called APOE4, has been shown to directly affect Lewy body dementias, such as Parkinson’s disease. Two separate studies, published simultaneously, found that APOE4 directly regulates levels of alpha-synuclein, which clumps to form the nerve-damaging Lewy…
Biomarkers of brain inflammation could provide a useful means for classifying Parkinson’s and Alzheimer’s patients and defining the mechanisms underpinning each person’s disease. Testing for these biomarkers could support clinicians in providing precision medicine, by helping people with the progressive neurodegenerative disorders to choose treatments with a greater…
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