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    • #18573
      Robert Harris
      Participant

      I wonder if anyone has an up to date report on butyric acid fighting Parkinson’s from the intestines, and on niacin fighting inflammation in the gut caused by Parkinson’s? I’ve just recently glanced at articles from the “miracle cure” types and from respected authorities, such as NIMH.

    • #18587
      George Kapetanakis
      Participant

      I would be interested to find out too.

    • #18593
      David
      Participant

      I tried butyric acid, noticed no effect but this was just me, maybe the dose was wrong .

    • #18594
      George Kapetanakis
      Participant

      Thanks David

    • #18595
      David
      Participant

      You’re welcome George…  do keep us posted on what you find

    • #18600
      Cemal
      Participant

      ?

      • This reply was modified 4 months, 2 weeks ago by Cemal.
    • #18602
      Philippe Joly
      Participant

      I use niacin (also named vitami B3) occasionally as a sleeping aid as it is a precursor to melatonin. I have not felt significant effects on parkinson’s symptoms but I consider it could be a bonus.

      I tried butyric acid also with no noticeable effects. Likewise with a couple other products. It seems now to me interesting to monitor the news flow on such still-promising products but not try them until a more accurate protocole and its actual performances are published.

    • #18603
      Philippe Joly
      Participant

      I use niacin (also named vitami B3) occasionally as a sleeping aid as it is a precursor to melatonin. I have not felt significant effects on parkinson’s symptoms but I consider it could be a bonus.

      I tried butyric acid also with no noticeable effects. Likewise with a couple other products. It seems now to me interesting to monitor the news flow on such still-promising products but not try them until a more accurate protocole and its actual performances are published.

    • #18604
      Russ Hudson
      Participant

      I take niacin and butyric acid supplements. It has reversed my Parkinson’s. No more tremors, anxiety, movement dreams, difficulty writing, feeling hot, brain fog.

      I take 12 pills a day of butyric acid supplements, six in the morning and six at night.

    • #18610
      Robert Harris
      Participant

      Okay, let’s see if we can discover why natural remedies are so often shoved aside by the pharmaceutical industry:

      1. A remedy must be proven to be SAFE and EFFECTIVE before it can be declared a genuine remedy.

      2. To prove a remedy is safe and effective, several rounds of development and testing are necessary. For a new chemical, the cost to big pharma is often about a billion dollars, what with one in 5000 compounds ever making it to human testing.

      3. The reward to big pharma for taking a billion-dollar risk is a 17-year patent, which allows them to be the monopolistic sellers of the new drug. They can then sell the drug for $50 a pill or more.

      4. Natural remedies would cost less to vet, but would still require testing for effectiveness in drug trials.

      5. What would be big pharma’s reward? They could sell the drug–but so could every other drug company, health food store, grocery store supplements department, and so on. A pill might sell for a nickle a pill.

      6. It’s not worth the time and effort for big pharma to test freely available natural remedies.

      7. As much as I  hate to say, “The government should do it,” the feds should dedicate a lot more dough into research, the results of which would be available to everyone. (They do some of this now.)

      8. When you look at the natural remedy stuff  in the vitamin store, note that they use the world’s biggest weasel word: “supports.” Our product supports  heart health. Then the label might include, “This product is not intended to prevent, treat, or cure any  health condition.” Or something to that effect.

    • #18611
      Robert Harris
      Participant

      Russ:

      What is the strength of your pills? Do you take straight butyric acid or GABA?

    • #18625
      Robert Houtman
      Participant

      Hi Russ

      I also take Butyric Acid but much less than you do. I also take Shark Liver Oil.  I would be very interested in knowing what brand of Butyric Acid you take and also what type you take Sodium Butyrate or Calcium Butyrate? Please could you also tell me what Niacin you take?

    • #18629
      Russ Hudson
      Participant

      Flush free Niacin, 500 mg, one pill a day.
      Calcium/Magnesium Butyrex Complex, Calcium 480 mg, Magnesium 240 mg, Butyric Acid 3.6 g. Serving size six capsules, taken twice a day.

    • #18638
      Rob Stehlin
      Participant

      I suffer from low butyrate ALSO and have some questions for all:

      1.  Prior to taking butyrate, did you test your SCFA levels?

      2a.  Prior to taking butyrate, did you have your gut microbiome sequenced in order to determine levels of bacteria and fungi (in particular the ones that produce SCFA’S)?

      2.  Prior to taking butyrate, did you notice the loss of body odor?  If so, did it return after you starting taking a butyrate supplement?

      3.  Prior to taking butyrate, did you notice your flatulent lost its odor?

      4.  Prior, during, post taking butyrate, did anyone test for Organic Acids, Chemical Toxins, Heavy Metals or Mold? IF so what did you find out?

       

       

    • #18675
      Murray Zipf
      Participant

      I was diagnosed 4 years ago- all the classic symptoms- loss of movement left hand arm foot , trouble walking, brain fog, soft voice, could speak clearly, violent dreams

      I’ve been taking same as russ 6 Butyrex twice daily , 1 niacin/day for 3 months now plus 1 madopar (levadopa) 250/2~3/day  for 2 months

      I feel good – lost my brain fog, talk clearly,can participate in conversation, got energy and balance, can walk without stumbling, can play tennis , can tie my fishing line almost feel normal again

      I take bioceutical 2 adrenoplex /twice daily , 1mthf/day, 1zinc sustain/ day for 2 years this got rid of the crazy violent dreams and cramps and got my taste back

      I lost 20kg, healthy BMI

      I also do wim hof breathing daily , cold showers daily, ice bath 2~3/wk

      I take tea spoon prebiotics 2/day, 1 Probiotic/day. No more constipation

    • #18682
      Philippe Joly
      Participant

      Thank you Russ and Murray for sharing details on butyric acid product quantity and quality. I could be interested to try again, but I have a question yet:

      – I understand your dosage is quite higher than the manufacturer recommends. Do you have other information on maximum intake and have you noticed adverse side effects.

      Thanks again for your contributions

      Philippe

       

       

       

    • #18686
      Rob Stehlin
      Participant

      Russ and Murray,

      Have either of you tested to see why you are not producing butyrate?

    • #18687
      Russ Hudson
      Participant

      Phillipe, the label on the container says serving size = six capsules, which I take twice a day.

      Rob, nope I’ve never tested to see why I’m not producing butyrate. It’s most likely something which, in some people, declines with age.

    • #18689
      Murray Zipf
      Participant

      Phillipe

      no adverse side effects (Except for just about choking on a handful of pills)

      I noticed improved bowel movement first which sort of tells me it’s not placebo effect

      then slowly started noticing improvements in all symptoms

       

    • #18697
      Philippe Joly
      Participant

      Thank you for your answers. They are comforting and I feel like trying again, which I will probably do around end of June, as I have a meeting with a new neurologist around mid June and I don’t want to complicate the picture of my symptoms before that. But I ‘ve already bought it, so here we are, and I will let you know for sure if anything good happens as you have been kind with your advice.I have read various articles which point the same way, but I have not been able to figure out how to copy the links yet for whoever is interested !

    • #18698
      Robert Houtman
      Participant

      Hi Russ and Murray

      I have started on the Butyrate but the recommended dosage is 2 capsules three times a day which equates to 6 capsules a day not the 12 you are taking.  Are the directions different on my Butyrate to yours or are you doubling up?  I am very keen to give Butyrate a realistic go.

       

    • #18716
      Murray Zipf
      Participant

      Name- butyrex

      serving size: 6 capsule

      suggested use: 1-2 capsules with each meal

      looks like we’re taking double the recommended dose

    • #18719
      Russ Hudson
      Participant

      Butyrate is a short-chain fatty acid (SCFA). Fatty acids are the building blocks of fats that our cells need to function. Butyrate is made when the bacteria living in our guts ferment otherwise indigestible fibers from grains, beans, onions, bananas, and other foods rich in complex carbs.

      Butyrate is the preferred energy source for the cells in your colon wall. It is essential for maintaining a healthy barrier between the colon and bloodstream and it prevents inflammation in the gut.

      Proponents:
      •Is a major energy source for colon cells
      •Believed to help prevent colon cancer
      •Increases mitochondrial activity
      •Prevents toxins from crossing the gut barrier
      •Improves insulin sensitivity
      •Promotes healthy weight
      •Fight inflammation
      •Prevents the growth of pathogenic bacteria
      •Protects the brain

      Skeptics:
      •Strong odor
      •Lack of high-quality human research
      •Difficult to separate butyrate from other short-chain fatty acids

      1) Gut Health

      Butyrate is essential for maintaining a healthy environment in the gut. In the human colon, anaerobic bacteria such as Clostridium butyricum, Roseburia intestinalis, and Faecalibacterium prausnitzii ferment carbohydrates and produce short-chain fatty acids (SCFAs): acetate, propionate, and butyrate [3, 10, 11].

      Colon Cell Energy Source

      Butyrate nourishes the colon wall, maintains a healthy lining and barrier function of the colon, and prevents intestinal inflammation [4].

      In the mitochondria of colon cells, 70-90% of butyrate is oxidized into acetyl-CoA, which is then used to generate large quantities of ATP, the primary form of cellular energy [12].

      If you don’t have enough butyrate-producing bacteria in your gut, you may be more likely to develop diarrhea, inflammatory bowel disease (IBD), and even colon cancer [13, 14, 15, 16, 17].

      Inflammatory Bowel Disease

      Short-chain fatty acids, especially butyrate, can reduce the symptoms of inflammatory bowel disease (IBD). In one study of 13 people with Crohn’s disease, a type of IBD, butyrate supplements improved 69% of cases, with symptoms completely disappearing in 54% (seven participants) [18, 19, 20, 21].

      There are a variety of approaches for using butyrate to manage IBD and colitis. The treatment strategies range from a high-fiber diet to butyrate-producing probiotics, coated butyrate tablets, and rectal enemas [22, 23].

      Diarrhea & Gut Inflammation

      Resistant starch is a type of soluble fiber that your gut bacteria can ferment into butyrate. A diet containing lots of resistant starch improved diarrhea in a trial of 57 baby boys [24].

      Butyrate can also prevent inflammation and stomach ulcers caused by alcohol. Mice given butyrate before alcohol had less inflammation and damage to the lining of their stomachs [25].

      Sodium butyrate in combination with other SCFAs and silicon dioxide was also shown to benefit traveler’s diarrhea, a condition common among those who travel to exotic countries [26].

      According to a great many studies, butyrate is vital for healthy gut flora, controlling inflammation, and maintaining a strong intestinal barrier.

      2) Inflammation

      Butyrate suppresses the activity of cells and proteins that drive inflammation [27].

      In one study on human cells, butyrate drastically reduced the activity of interleukin-12 (IL-12), an inflammatory cytokine, while increasing interleukin-10 (IL-10), which is generally anti-inflammatory [28].

      In mice, butyrate-producing dietary fibers counteracted inflammation and illness caused by bacterial toxins. The inflammatory cytokines inhibited by butyrate included interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), and interferon gamma (INF-y) [29].

      Immune Response

      Butyrate may reduce inflammation by increasing the activity of immune cells called regulatory T cells or Tregs. These specialized cells stop other immune cells – Th1, Th2, and Th17 – in their tracks, before they lose control. In turn, Tregs prevent the lining of the gut from overreacting to harmless food proteins [30].

      Gut Barrier

      Butyrate also strengthens the barrier formed by cells in the colon wall, thus preventing microbes and bacterial toxins from invading the bloodstream [31].

      Inflammation Due to Aging

      As we grow older, inflammation increases throughout our bodies. In aging mice, a diet high in fiber that produces butyrate counteracted age-related increases in inflammation, suggesting that butyrate may be especially helpful to the elderly. Human studies will be required to confirm this benefit, however [32].

      Animal and cell studies show that butyrate inhibits inflammatory cytokines and prevents inflammatory bacterial toxins from entering the bloodstream.

      3) Fine-Tuning the Immune System

      As an HDAC inhibitor, butyrate adjusts the immune system in a number of ways.

      HDAC inhibitors improve the tumor-targeting abilities of immune cells like T cells and natural killer cells; they are currently under investigation as potential cancer drugs. This class of compounds also reduces many inflammatory signals and increases Tregs, a type of white blood cell that prevents allergies and autoimmunity [33, 34, 35].

      Butyrate more specifically protects the gut barrier and prevents pathogens and other harmful agents from crossing into the bloodstream [36].

      4) Brain and Nerve Cells

      The gut and the microbiome strongly affect the brain. Your gut bacteria “talk” to your cells by releasing butyrate, which (as an HDAC inhibitor) turns on certain genes [37].

      Cognition

      Butyrate may improve learning and long-term memory. Similar to exercise, sodium butyrate increased brain-derived neurotrophic factor (BDNF) in mice. Simply put, butyrate supplies “brain food” (neuro = brain, trophic = food) to the hippocampus, the brain’s hub for memory and emotions. This gives birth to new neurons, called neurogenesis, a process that can reshape the brain [38].

      The effect of butyrate supplements or intestinal butyrate concentration on cognition has not been tested in humans. However, this effect has been repeated multiple times in animals, and probiotics containing butyrate-producing bacteria have been associated with reduced stress in humans. Human trials on butyrate and cognition are likely to be next [39, 40, 32, 41].

      Brain Injury

      There’s a huge overlap between cognitive enhancement and recovery from brain damage. Both rely on neurogenesis, a process that replenishes and reshapes the brain.

      In a mouse study, sodium butyrate given after a stroke supported the development of new nerve cells in the damaged areas. It also strengthened the blood-brain barrier in mice with brain trauma, which helped them recover. Butyrate-producing bacteria also strengthened this barrier in mice [42, 43, 44].

      Clostridium butyricum, a butyrate-producing species of bacteria, may help manage vascular dementia, a disease whereby blood vessel blockages prevent brain cells from getting enough oxygen. In a mouse study, animals with C. butyricum in the gut experienced less cell death in their brains [45].

      These effects have not yet been investigated in human trials.

      Nerve Damage

      Butyrate may also help manage other types of nerve damage. In guinea pigs, sodium butyrate protected nerve cells in the ear after treatment with antibiotics, thus preventing hearing loss [46].

      Mice with brain damage due to lack of oxygen fared better when they were given the butyrate-producing bacteria Clostridium butyricum before the injury [47].

      Sodium butyrate also prevented the death of nerve cells in the spine of mice with spinal muscular atrophy [48].

      Animal studies show that butyrate is neuroprotective and may improve memory and reduce the impact of brain trauma. Human trials will be needed to confirm these effects.

      Food Sources

      You get can butyrate from food. For example, butyric acid abounds dairy products, especially butter. Butter, which gave butyrate its name, contains about 3 to 4% of butyrate in the form of tributyrin. Plant oils also contain butyrate to some extent [115, 116, 117].

      Eating more fiber increases butyrate production by some bacteria in your gut. There is generally an association between a higher intake of plant foods and increased levels of short-chain fatty acids (SCFAs), including butyrate, in stools. However, not all plant-based foods yield butyrate; for example, diets rich in fruit or starch are associated with high butyrate levels in the gut, but starch-free wheat bran is not [118, 119, 120, 121].

      Depending on the composition of your gut flora, the following fibers may encourage them to produce SFCAs, including butyrate [122, 123, 124]:
      •Inulin: artichokes, garlic, leeks, onions, and asparagus
      •Fructooligosaccharides (FOS): fruits and vegetables, including bananas, onions, garlic, and asparagus
      •Resistant starch: cooked and cooled rice, potatoes and green bananas
      •Pectin: apples, apricots, carrots, oranges, and others
      •Oat bran
      •Arabinoxylan
      •Guar gum
      •Arabinogalactan
      •Hi-Maize, potato or plantain starch flours

    • #18720
      Russ Hudson
      Participant

      I buy Butyrex® by T.E.Neesby online. It says the serving size is six capsules. I immediately started feeling better when I started in Sep 2018.

    • #19063
      samantha
      Participant

      I have read that “There are 3 forms of vitamin B3 — niacin (also known as nicotinic acid), nicotinamide, and nicotinamide riboside. All 3 are related and used by the body in the same way. As the body cannot store this vitamin, having a healthy diet that contains adequate vitamin B3 is essential. Fortunately, it is found in many different foods including turkey, tuna, cereal, mushrooms and peanuts. While much of the previous research into vitamin B3 in Parkinson’s has focused on the potential benefits of niacin, this research used the nicotinamide riboside form of vitamin B3. The new results suggest that this form of the vitamin may also have beneficial effects in Parkinson’s.” here are 3 forms of vitamin B3 — niacin  (also known as nicotinic acid, more on Canada Drugs Direct), nicotinamide, and nicotinamide riboside. All 3 are related and used by the body in the same way.

      As the body cannot store this vitamin, having a healthy diet that contains adequate vitamin B3 is essential. Fortunately, it is found in many different foods including turkey, tuna, cereal, mushrooms and peanuts.

      While much of the previous research into vitamin B3 in Parkinson’s has focused on the potential benefits of niacin, this research used the nicotinamide riboside form of vitamin B3. The new results suggest that this form of the vitamin may also have beneficial effects in Parkinson’s.

    • #19076
      Ron Work
      Participant

      How soon did the tremors slow or go away?

    • #19092
      Russ Hudson
      Participant

      “How soon did the tremors slow or go away?”

      Within a month or two

    • #19125
      Emmi Beutel
      Participant

      I have a question about the Butyric Acid and Niacin:

      do you take it every day longterm, by that I mean for the rest of your life.

       

    • #19126
      Russ Hudson
      Participant

      “I have a question about the Butyric Acid and Niacin: do you take it every day longterm, by that I mean for the rest of your life.”

      I would say yes, I’ll take it for the rest of my life. I’m sure the side effects of not taking it, the return of Parkinson’s, would be worse.

    • #19128
      Emmi Beutel
      Participant

      Russ,

      does your Doctor or Neurologist know about butyric acid and that you take it and does he approve it?Is it save to take so much each day?

    • #19129
      Fran
      Participant

      Russ

       

      thank you so much for sharing.  Do you take 6 twice a day or do you split the 12 up a particular way throughout the day?

      Thank you !

    • #19455
      Rob Stehlin
      Participant

      Russ – I still keep asking what killed the gut microbiome stopping the production of butyrate.  This is the “WHY”I am searching for.  I am searching the connection between my gut dysbiosis and my toxicology test.  The gut dysbiosis is the key to pre-parkinson’s.  It is the dysbiosis that allows the transfer of mis folded proteins or toxinis to enter the ENS and then the CNS via the vagal nerve.

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