Viewing 44 reply threads
  • Author
    Posts
    • #18573
      Robert Harris
      Participant

      I wonder if anyone has an up to date report on butyric acid fighting Parkinson’s from the intestines, and on niacin fighting inflammation in the gut caused by Parkinson’s? I’ve just recently glanced at articles from the “miracle cure” types and from respected authorities, such as NIMH.

    • #18587
      George Kapetanakis
      Participant

      I would be interested to find out too.

    • #18593
      David
      Participant

      I tried butyric acid, noticed no effect but this was just me, maybe the dose was wrong .

      • #20059
        Beth T Browne
        Participant

        I saw my Parkinson’s doctor last week.  I told her about some having good results from using these items.  She was not recommending it.  She didn’t say it was harmful, she just said it usual provides a false result, like when tests give some the real medication and others receive a fake one.

      • #21424
        David
        Participant

        I am now taking butyric acid again and  finding it helps me to feel better

    • #18594
      George Kapetanakis
      Participant

      Thanks David

    • #18595
      David
      Participant

      You’re welcome George…  do keep us posted on what you find

    • #18600
      Cemal
      Participant

      ?

      • This reply was modified 1 year, 5 months ago by Cemal.
    • #18602
      Philippe Joly
      Participant

      I use niacin (also named vitami B3) occasionally as a sleeping aid as it is a precursor to melatonin. I have not felt significant effects on parkinson’s symptoms but I consider it could be a bonus.

      I tried butyric acid also with no noticeable effects. Likewise with a couple other products. It seems now to me interesting to monitor the news flow on such still-promising products but not try them until a more accurate protocole and its actual performances are published.

    • #18603
      Philippe Joly
      Participant

      I use niacin (also named vitami B3) occasionally as a sleeping aid as it is a precursor to melatonin. I have not felt significant effects on parkinson’s symptoms but I consider it could be a bonus.

      I tried butyric acid also with no noticeable effects. Likewise with a couple other products. It seems now to me interesting to monitor the news flow on such still-promising products but not try them until a more accurate protocole and its actual performances are published.

    • #18604
      Russ Hudson
      Participant

      I take niacin and butyric acid supplements. It has reversed my Parkinson’s. No more tremors, anxiety, movement dreams, difficulty writing, feeling hot, brain fog.

      I take 12 pills a day of butyric acid supplements, six in the morning and six at night.

      • #19912
        Beth T Browne
        Participant

        Hi Russ,

        I was amazed in reading your comment about how the items you mention that you take 12 of a day, had helped you so much. I was diagnoised this year, but we feel I had it a year before. It started with tremors, then after an MRI of my brain, she said I was lacking Dopamine. The did not agree with me. Made me so nauseous. She now has me taking three a day of Dopamine, 15%, I get from Amazon. So far it has not done anything. Then, 2 weeks before Thanksgiving, I lost my sense of taste. Smell is okay. That has been the worse for me. I just don’t feel like eating. And, I only weight 93, so I need to eat. I have nothing from anyone who has lost their taste, and how they are handling it. Anyway, I too, am wondering if your PD doc feels what you are taking that is working is okay with it, and if there could be side effects. Thank you.
        Beth

      • #21353
        Bolt Upright
        Participant

        Hello Russ, I am so excited about your results. I am wondering.  Your profile says you were self diagnosed.  Since that self diagnosis, have you been diagnosed by an MD?

        Don’t get me wrong, I do think you are onto something.  In fact there is a recent study that came out showing 250 mg of B3 stopped disease progression in 47 out of 47 people in a trial.
        Niacin Enhancement for Parkinson’s Disease:
        https://www.researchgate.net/publication/352486597_Niacin_Enhancement_for_Parkinson’s_Disease_An_Effectiveness_Trial

      • #21404
        Allison
        Participant

        WOW amazing thanks for the feedback !

    • #18610
      Robert Harris
      Participant

      Okay, let’s see if we can discover why natural remedies are so often shoved aside by the pharmaceutical industry:

      1. A remedy must be proven to be SAFE and EFFECTIVE before it can be declared a genuine remedy.

      2. To prove a remedy is safe and effective, several rounds of development and testing are necessary. For a new chemical, the cost to big pharma is often about a billion dollars, what with one in 5000 compounds ever making it to human testing.

      3. The reward to big pharma for taking a billion-dollar risk is a 17-year patent, which allows them to be the monopolistic sellers of the new drug. They can then sell the drug for $50 a pill or more.

      4. Natural remedies would cost less to vet, but would still require testing for effectiveness in drug trials.

      5. What would be big pharma’s reward? They could sell the drug–but so could every other drug company, health food store, grocery store supplements department, and so on. A pill might sell for a nickle a pill.

      6. It’s not worth the time and effort for big pharma to test freely available natural remedies.

      7. As much as I  hate to say, “The government should do it,” the feds should dedicate a lot more dough into research, the results of which would be available to everyone. (They do some of this now.)

      8. When you look at the natural remedy stuff  in the vitamin store, note that they use the world’s biggest weasel word: “supports.” Our product supports  heart health. Then the label might include, “This product is not intended to prevent, treat, or cure any  health condition.” Or something to that effect.

    • #18611
      Robert Harris
      Participant

      Russ:

      What is the strength of your pills? Do you take straight butyric acid or GABA?

    • #18625
      Robert Houtman
      Participant

      Hi Russ

      I also take Butyric Acid but much less than you do. I also take Shark Liver Oil.  I would be very interested in knowing what brand of Butyric Acid you take and also what type you take Sodium Butyrate or Calcium Butyrate? Please could you also tell me what Niacin you take?

    • #18629
      Russ Hudson
      Participant

      Flush free Niacin, 500 mg, one pill a day.
      Calcium/Magnesium Butyrex Complex, Calcium 480 mg, Magnesium 240 mg, Butyric Acid 3.6 g. Serving size six capsules, taken twice a day.

      • #20054
        Christina
        Participant

        Russ, I purchased the Butyrex that you said you use, the T. E. Neesby.  I have yet to start it because it has 240 mg of Magnesium hydroxide.  I also take Magnesium L-Threonate.  I take the Magnesium L-Threonate bc of a study published in 2019.  It was only a mouse study but it stated that it crosses the blood brain barrier and (in mice at least) slowed motor decline and neuronal loss.  So I have two questions, do you have any recommendations of a source of Butyric acid that is not coupled with magnesium?  And, does anyone have any personal experience with or further knowledge on Magnesium L-Threonate?  (Please, I understand we are not mice so no need to emphasize that aspect of this equation.)

         

    • #18638
      Rob Stehlin
      Participant

      I suffer from low butyrate ALSO and have some questions for all:

      1.  Prior to taking butyrate, did you test your SCFA levels?

      2a.  Prior to taking butyrate, did you have your gut microbiome sequenced in order to determine levels of bacteria and fungi (in particular the ones that produce SCFA’S)?

      2.  Prior to taking butyrate, did you notice the loss of body odor?  If so, did it return after you starting taking a butyrate supplement?

      3.  Prior to taking butyrate, did you notice your flatulent lost its odor?

      4.  Prior, during, post taking butyrate, did anyone test for Organic Acids, Chemical Toxins, Heavy Metals or Mold? IF so what did you find out?

       

       

    • #18675
      Murray Zipf
      Participant

      I was diagnosed 4 years ago- all the classic symptoms- loss of movement left hand arm foot , trouble walking, brain fog, soft voice, could speak clearly, violent dreams

      I’ve been taking same as russ 6 Butyrex twice daily , 1 niacin/day for 3 months now plus 1 madopar (levadopa) 250/2~3/day  for 2 months

      I feel good – lost my brain fog, talk clearly,can participate in conversation, got energy and balance, can walk without stumbling, can play tennis , can tie my fishing line almost feel normal again

      I take bioceutical 2 adrenoplex /twice daily , 1mthf/day, 1zinc sustain/ day for 2 years this got rid of the crazy violent dreams and cramps and got my taste back

      I lost 20kg, healthy BMI

      I also do wim hof breathing daily , cold showers daily, ice bath 2~3/wk

      I take tea spoon prebiotics 2/day, 1 Probiotic/day. No more constipation

      • #20022
        Beth T Browne
        Participant

        Hi Murray. Just read your May note and you are the only person I have heard lost their taste. I just lost mine last month, so I am very interested in how you got it back. I was just diagnosed in July of this year, but may have had PD last year, as I had sleep loss, and my right hand was shaking a lot. Anyway, I have never heard of Butyric acid supplements. I know of Niacin. I have heredity high cholesterol. I have always been petite, eat hardly any meat, etc. We tried taking me off of it, but no luck. Anyway right now, I really need to eat due to weight lost when I could not handle the Dopa/Levododpa 25/100. PD doc has me on 15% Dopamine. 2 in the am and 1 at lunch. It made me very dizzy when I took the 3rd one a night. She hopes I can eventually handle the prescription. This taste loss is not good, as I don’t have much desire to eat, and I can’t lose much more weight, even tho I am petite. I wonder why I have not been told about the Butyric Acid supplements. I take calcium as I also have osteoporosis, and I take Magnesium. I don’t have bad dreams, but sleep is a problem. My balance is not bad, but not good. I controlled constipation eating 2 prunes a day and drinking 1/2 bottle of ensure in blender with coconut milk and collagen. I also started taking Juice Plus veggies and greens, as I don’t eat enough of those. I was first told when diagnosed that I was lacking Dopamine and there were no other problems w/my brain. But I also have brain fog, or maybe more as I have some short term memory also. She said I didn’t have dementia but what if I am headed that way. Anyway, right now, I just need to get my taste back. My smell is okay. So glad you are doing so well. This is an awful thing to live with. Beth

    • #18682
      Philippe Joly
      Participant

      Thank you Russ and Murray for sharing details on butyric acid product quantity and quality. I could be interested to try again, but I have a question yet:

      – I understand your dosage is quite higher than the manufacturer recommends. Do you have other information on maximum intake and have you noticed adverse side effects.

      Thanks again for your contributions

      Philippe

       

       

       

    • #18686
      Rob Stehlin
      Participant

      Russ and Murray,

      Have either of you tested to see why you are not producing butyrate?

    • #18687
      Russ Hudson
      Participant

      Phillipe, the label on the container says serving size = six capsules, which I take twice a day.

      Rob, nope I’ve never tested to see why I’m not producing butyrate. It’s most likely something which, in some people, declines with age.

    • #18689
      Murray Zipf
      Participant

      Phillipe

      no adverse side effects (Except for just about choking on a handful of pills)

      I noticed improved bowel movement first which sort of tells me it’s not placebo effect

      then slowly started noticing improvements in all symptoms

       

    • #18697
      Philippe Joly
      Participant

      Thank you for your answers. They are comforting and I feel like trying again, which I will probably do around end of June, as I have a meeting with a new neurologist around mid June and I don’t want to complicate the picture of my symptoms before that. But I ‘ve already bought it, so here we are, and I will let you know for sure if anything good happens as you have been kind with your advice.I have read various articles which point the same way, but I have not been able to figure out how to copy the links yet for whoever is interested !

    • #18698
      Robert Houtman
      Participant

      Hi Russ and Murray

      I have started on the Butyrate but the recommended dosage is 2 capsules three times a day which equates to 6 capsules a day not the 12 you are taking.  Are the directions different on my Butyrate to yours or are you doubling up?  I am very keen to give Butyrate a realistic go.

       

    • #18716
      Murray Zipf
      Participant

      Name- butyrex

      serving size: 6 capsule

      suggested use: 1-2 capsules with each meal

      looks like we’re taking double the recommended dose

    • #18719
      Russ Hudson
      Participant

      Butyrate is a short-chain fatty acid (SCFA). Fatty acids are the building blocks of fats that our cells need to function. Butyrate is made when the bacteria living in our guts ferment otherwise indigestible fibers from grains, beans, onions, bananas, and other foods rich in complex carbs.

      Butyrate is the preferred energy source for the cells in your colon wall. It is essential for maintaining a healthy barrier between the colon and bloodstream and it prevents inflammation in the gut.

      Proponents:
      •Is a major energy source for colon cells
      •Believed to help prevent colon cancer
      •Increases mitochondrial activity
      •Prevents toxins from crossing the gut barrier
      •Improves insulin sensitivity
      •Promotes healthy weight
      •Fight inflammation
      •Prevents the growth of pathogenic bacteria
      •Protects the brain

      Skeptics:
      •Strong odor
      •Lack of high-quality human research
      •Difficult to separate butyrate from other short-chain fatty acids

      1) Gut Health

      Butyrate is essential for maintaining a healthy environment in the gut. In the human colon, anaerobic bacteria such as Clostridium butyricum, Roseburia intestinalis, and Faecalibacterium prausnitzii ferment carbohydrates and produce short-chain fatty acids (SCFAs): acetate, propionate, and butyrate [3, 10, 11].

      Colon Cell Energy Source

      Butyrate nourishes the colon wall, maintains a healthy lining and barrier function of the colon, and prevents intestinal inflammation [4].

      In the mitochondria of colon cells, 70-90% of butyrate is oxidized into acetyl-CoA, which is then used to generate large quantities of ATP, the primary form of cellular energy [12].

      If you don’t have enough butyrate-producing bacteria in your gut, you may be more likely to develop diarrhea, inflammatory bowel disease (IBD), and even colon cancer [13, 14, 15, 16, 17].

      Inflammatory Bowel Disease

      Short-chain fatty acids, especially butyrate, can reduce the symptoms of inflammatory bowel disease (IBD). In one study of 13 people with Crohn’s disease, a type of IBD, butyrate supplements improved 69% of cases, with symptoms completely disappearing in 54% (seven participants) [18, 19, 20, 21].

      There are a variety of approaches for using butyrate to manage IBD and colitis. The treatment strategies range from a high-fiber diet to butyrate-producing probiotics, coated butyrate tablets, and rectal enemas [22, 23].

      Diarrhea & Gut Inflammation

      Resistant starch is a type of soluble fiber that your gut bacteria can ferment into butyrate. A diet containing lots of resistant starch improved diarrhea in a trial of 57 baby boys [24].

      Butyrate can also prevent inflammation and stomach ulcers caused by alcohol. Mice given butyrate before alcohol had less inflammation and damage to the lining of their stomachs [25].

      Sodium butyrate in combination with other SCFAs and silicon dioxide was also shown to benefit traveler’s diarrhea, a condition common among those who travel to exotic countries [26].

      According to a great many studies, butyrate is vital for healthy gut flora, controlling inflammation, and maintaining a strong intestinal barrier.

      2) Inflammation

      Butyrate suppresses the activity of cells and proteins that drive inflammation [27].

      In one study on human cells, butyrate drastically reduced the activity of interleukin-12 (IL-12), an inflammatory cytokine, while increasing interleukin-10 (IL-10), which is generally anti-inflammatory [28].

      In mice, butyrate-producing dietary fibers counteracted inflammation and illness caused by bacterial toxins. The inflammatory cytokines inhibited by butyrate included interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), and interferon gamma (INF-y) [29].

      Immune Response

      Butyrate may reduce inflammation by increasing the activity of immune cells called regulatory T cells or Tregs. These specialized cells stop other immune cells – Th1, Th2, and Th17 – in their tracks, before they lose control. In turn, Tregs prevent the lining of the gut from overreacting to harmless food proteins [30].

      Gut Barrier

      Butyrate also strengthens the barrier formed by cells in the colon wall, thus preventing microbes and bacterial toxins from invading the bloodstream [31].

      Inflammation Due to Aging

      As we grow older, inflammation increases throughout our bodies. In aging mice, a diet high in fiber that produces butyrate counteracted age-related increases in inflammation, suggesting that butyrate may be especially helpful to the elderly. Human studies will be required to confirm this benefit, however [32].

      Animal and cell studies show that butyrate inhibits inflammatory cytokines and prevents inflammatory bacterial toxins from entering the bloodstream.

      3) Fine-Tuning the Immune System

      As an HDAC inhibitor, butyrate adjusts the immune system in a number of ways.

      HDAC inhibitors improve the tumor-targeting abilities of immune cells like T cells and natural killer cells; they are currently under investigation as potential cancer drugs. This class of compounds also reduces many inflammatory signals and increases Tregs, a type of white blood cell that prevents allergies and autoimmunity [33, 34, 35].

      Butyrate more specifically protects the gut barrier and prevents pathogens and other harmful agents from crossing into the bloodstream [36].

      4) Brain and Nerve Cells

      The gut and the microbiome strongly affect the brain. Your gut bacteria “talk” to your cells by releasing butyrate, which (as an HDAC inhibitor) turns on certain genes [37].

      Cognition

      Butyrate may improve learning and long-term memory. Similar to exercise, sodium butyrate increased brain-derived neurotrophic factor (BDNF) in mice. Simply put, butyrate supplies “brain food” (neuro = brain, trophic = food) to the hippocampus, the brain’s hub for memory and emotions. This gives birth to new neurons, called neurogenesis, a process that can reshape the brain [38].

      The effect of butyrate supplements or intestinal butyrate concentration on cognition has not been tested in humans. However, this effect has been repeated multiple times in animals, and probiotics containing butyrate-producing bacteria have been associated with reduced stress in humans. Human trials on butyrate and cognition are likely to be next [39, 40, 32, 41].

      Brain Injury

      There’s a huge overlap between cognitive enhancement and recovery from brain damage. Both rely on neurogenesis, a process that replenishes and reshapes the brain.

      In a mouse study, sodium butyrate given after a stroke supported the development of new nerve cells in the damaged areas. It also strengthened the blood-brain barrier in mice with brain trauma, which helped them recover. Butyrate-producing bacteria also strengthened this barrier in mice [42, 43, 44].

      Clostridium butyricum, a butyrate-producing species of bacteria, may help manage vascular dementia, a disease whereby blood vessel blockages prevent brain cells from getting enough oxygen. In a mouse study, animals with C. butyricum in the gut experienced less cell death in their brains [45].

      These effects have not yet been investigated in human trials.

      Nerve Damage

      Butyrate may also help manage other types of nerve damage. In guinea pigs, sodium butyrate protected nerve cells in the ear after treatment with antibiotics, thus preventing hearing loss [46].

      Mice with brain damage due to lack of oxygen fared better when they were given the butyrate-producing bacteria Clostridium butyricum before the injury [47].

      Sodium butyrate also prevented the death of nerve cells in the spine of mice with spinal muscular atrophy [48].

      Animal studies show that butyrate is neuroprotective and may improve memory and reduce the impact of brain trauma. Human trials will be needed to confirm these effects.

      Food Sources

      You get can butyrate from food. For example, butyric acid abounds dairy products, especially butter. Butter, which gave butyrate its name, contains about 3 to 4% of butyrate in the form of tributyrin. Plant oils also contain butyrate to some extent [115, 116, 117].

      Eating more fiber increases butyrate production by some bacteria in your gut. There is generally an association between a higher intake of plant foods and increased levels of short-chain fatty acids (SCFAs), including butyrate, in stools. However, not all plant-based foods yield butyrate; for example, diets rich in fruit or starch are associated with high butyrate levels in the gut, but starch-free wheat bran is not [118, 119, 120, 121].

      Depending on the composition of your gut flora, the following fibers may encourage them to produce SFCAs, including butyrate [122, 123, 124]:
      •Inulin: artichokes, garlic, leeks, onions, and asparagus
      •Fructooligosaccharides (FOS): fruits and vegetables, including bananas, onions, garlic, and asparagus
      •Resistant starch: cooked and cooled rice, potatoes and green bananas
      •Pectin: apples, apricots, carrots, oranges, and others
      •Oat bran
      •Arabinoxylan
      •Guar gum
      •Arabinogalactan
      •Hi-Maize, potato or plantain starch flours

      • #20061
        Christina
        Participant

        Russ, Thank you for all of that information.  That was very time consuming I’m sure.  I am grateful for your research.  I previously inquired about this and I don’t mean to be a pest about it but I do wonder if you know about Magnesium L-Threonate and if you have an opinion on that?  I have found that MCT oil is helping me.

        The more proactive we all are with researching and trying different methods the better!  Together we can make some difference in discovering how to help ourselves!

         

    • #18720
      Russ Hudson
      Participant

      I buy Butyrex® by T.E.Neesby online. It says the serving size is six capsules. I immediately started feeling better when I started in Sep 2018.

      • #20021
        Terry Sullivan
        Participant

        I bought the Butyrex complex by T.E. Neesby and the label does say “Serving Size:  6 capsules,” but it also says “Suggested Use: 1-2 capsules with each meal.” So, Russ, you’re taking twice the suggested daily dose. Did you ever try just six capsules a day?

        I just started taking this today. My Parkinson’s has greatly affected my balance, but so far I’ve had no trembling.

         

    • #19063
      samantha
      Participant

      I have read that “There are 3 forms of vitamin B3 — niacin (also known as nicotinic acid), nicotinamide, and nicotinamide riboside. All 3 are related and used by the body in the same way. As the body cannot store this vitamin, having a healthy diet that contains adequate vitamin B3 is essential. Fortunately, it is found in many different foods including turkey, tuna, cereal, mushrooms and peanuts. While much of the previous research into vitamin B3 in Parkinson’s has focused on the potential benefits of niacin, this research used the nicotinamide riboside form of vitamin B3. The new results suggest that this form of the vitamin may also have beneficial effects in Parkinson’s.” here are 3 forms of vitamin B3 — niacin  (also known as nicotinic acid, more on Canada Drugs Direct), nicotinamide, and nicotinamide riboside. All 3 are related and used by the body in the same way.

      As the body cannot store this vitamin, having a healthy diet that contains adequate vitamin B3 is essential. Fortunately, it is found in many different foods including turkey, tuna, cereal, mushrooms and peanuts.

      While much of the previous research into vitamin B3 in Parkinson’s has focused on the potential benefits of niacin, this research used the nicotinamide riboside form of vitamin B3. The new results suggest that this form of the vitamin may also have beneficial effects in Parkinson’s.

    • #19076
      Ron Work
      Participant

      How soon did the tremors slow or go away?

    • #19092
      Russ Hudson
      Participant

      “How soon did the tremors slow or go away?”

      Within a month or two

    • #19125
      Emmi Beutel
      Participant

      I have a question about the Butyric Acid and Niacin:

      do you take it every day longterm, by that I mean for the rest of your life.

       

    • #19126
      Russ Hudson
      Participant

      “I have a question about the Butyric Acid and Niacin: do you take it every day longterm, by that I mean for the rest of your life.”

      I would say yes, I’ll take it for the rest of my life. I’m sure the side effects of not taking it, the return of Parkinson’s, would be worse.

    • #19128
      Emmi Beutel
      Participant

      Russ,

      does your Doctor or Neurologist know about butyric acid and that you take it and does he approve it?Is it save to take so much each day?

    • #19129
      Fran
      Participant

      Russ

       

      thank you so much for sharing.  Do you take 6 twice a day or do you split the 12 up a particular way throughout the day?

      Thank you !

    • #19455
      Rob Stehlin
      Participant

      Russ – I still keep asking what killed the gut microbiome stopping the production of butyrate.  This is the “WHY”I am searching for.  I am searching the connection between my gut dysbiosis and my toxicology test.  The gut dysbiosis is the key to pre-parkinson’s.  It is the dysbiosis that allows the transfer of mis folded proteins or toxinis to enter the ENS and then the CNS via the vagal nerve.

    • #19481
      joan
      Participant

      If any of this can help slow down or relieve the PD symptoms we should hope information would be made available to us and our doctors. I’m willing to give it a try. PD is awful.

      • #21406
        Beth T Browne
        Participant

        Joan, I am f inding my doctor won’t talk about any thing except what has been tested and proven.  I have recently changed doctors, but only have seen him once.  So, maybe he is the same.  Since I cannot handle the LevaDopa, I am trying Mannitol, and I recently started taking Niacinamide, 500mg, 1 a day.  I am petite only weighing 94, so I am concerned about taking large doses of anything. But I am thinking about trying the Butyric.  I take a lot of supplements include B vitamins.  And, with osteoporosis, I have taken calcium/mag for years, but not doing anything for my Parkinson.

    • #19484
      Daniel Best
      Participant

      Hi Russ,

      Super-interesting information!  In addition to the butyric acid and niacin, are you taking any of the more standard PD medications?

    • #19488
      Todd Kitten
      Participant

      Hi Rob,

      I’m interested in your questions and comments about butyric acid. Where does one get their SCFA levels tested? Also, I’m aware of companies performing microbiome sequencing, but I would be interested to know who you used if you’ve had that done.

      Thanks.

    • #19492
      Daniel Best
      Participant

      Could the results be due to any other medications?  Are you taking C/L etc?

    • #19499
      Murray Zipf
      Participant

      I’m still happy with my results taking 6 Butyric x2 daily

      I stopped niacin b3 I used to go bright red

      i feel the supplements are only part of the story

      i walk 45 minutes/ day
      3-4 minute ice bath daily reignites the whole body autoimmune system

      wim hof breathing( google him) daily Supercharges oxygen throughout your body

    • #19500
      Russ Hudson
      Participant

      Daniel, I don’t take any other PD medicines.

    • #19506
      Rob Stehlin
      Participant

      Todd –  you can get a SCFA test done at Great Plains Lab. I use them for all my testing. Taking Butyric Acid does not answer why and is probably why few see any results.   Detoxing and restoring the gut microbiome back to where it produces SCFA’s is what we need to do.  Just a question – do you have body odor?  If you do not, it is a sure indicator you have low butyrate.

       

    • #19516
      Todd Kitten
      Participant

      Hi Rob. Thanks for your response. I saw that you’ve mentioned the body odor issue several times. I’m surprised to hear about a lack of body odor indicating a problem. I thought people with Parkinson’s had an unusual body odor that some people can detect and that dogs have been trained to detect. Is the body odor you’re referring to similar to that of the butyric acid pills?

    • #19535
      Andrew L.
      Participant

      Never tried Butyrate. have been on Niacin for 25 years for high cholesterol, diagnosed with Parkinson’s just a few years ago.

    • #19903
      George Harison
      Participant

      Which is the best brand of butyrate acid?  If you do an Amazon search you get over a dozen brands!  Some contain Magnesium and Calcium, others sulfur.  Others contain bio- availability enhancers.  Then there’s the dosage (mg) per capsule and recommended serving sizes.

      • #20076
        Beth T Browne
        Participant

        I think we should try anything that is not harmful.  Although my doctor said butyrate acids does not cure PD, and it is okay to try, it seems to work for some and some not so.  I was also told losing your taste is one of Parkinson’s symptoms, and that it doesn’t come back.  I was tasted for the virus twice, and it was negative, and I have no symptoms.  However, I sense my taste is starting to return some, so what am I taking causing that to happen?  If it generally doesn’t return with PD, I must be doing something right.  No one has respond to me regarding their lost of taste, so I have nothing to go on.  I could not handle the prescripton for Dopamine, so I take only 45% (twice a day) with the hopes I will be able to handle the stronger form.  My tremors have not changed, and get worse when I get upset or have problems to solve.  My walking is okay.  I some times have a problem swallowing pills.  I have no bad dreams.  My balance is off some.  In the mornings when I wake and look at the clock, I have double vision, but it goes away.  My hair is falling out badly.  My PD doc does not believe it is related to Parkinson’s, yet many of her women patients are commenting the same thing.  She believes it is something in the environment.  I live in Southern California.  My sleep is difficult and has been for two years, although I was only diagnosed in July of this year.  I think I had it last year as sleep was difficult, and I had tremors in my right hands.  I may try the butyrate acid to see if it helps my tremors.

    • #21395
      Bolt Upright
      Participant

      Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease

      by Tennekoon B. Karunaratne, Chijioke Okereke, Marissa Seamon, Sharad Purohit, Chandramohan Wakade and Amol Sharma

      mdpi.com/2072-6643/13/1/28/htm

      Abstract

      Dysbiosis is implicated by many studies in the pathogenesis of Parkinson’s disease (PD). Advances in sequencing technology and computing have resulted in confounding data regarding pathogenic bacterial profiles in conditions such as PD. Changes in the microbiome with reductions in short-chain fatty acid (SCFA)-producing bacteria and increases in endotoxin-producing bacteria likely contribute to the pathogenesis of PD. GPR109A, a G-protein coupled receptor found on the surface of the intestinal epithelium and immune cells, plays a key role in controlling intestinal permeability and the inflammatory cascade. The absence of GPR109A receptors is associated with decreased concentration of tight junction proteins, leading to increased intestinal permeability and susceptibility to inflammation. In inflammatory states, butyrate acts via GPR109A to increase concentrations of tight junction proteins and improve intestinal permeability. Niacin deficiency is exacerbated in PD by dopaminergic medications. Niacin supplementation has been shown to shift macrophage polarization from pro-inflammatory to an anti-inflammatory profile. Niacin and butyrate, promising nutrients and unique ligands for the G protein-coupled receptor GPR109A, are reviewed in this paper in detail.

    • #21396
      Bolt Upright
      Participant

      Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease

      by Tennekoon B. Karunaratne, Chijioke Okereke, Marissa Seamon, Sharad Purohit, Chandramohan Wakade and Amol Sharma

      mdpi.com/2072-6643/13/1/28/htm

      Abstract

      Dysbiosis is implicated by many studies in the pathogenesis of Parkinson’s disease (PD). Advances in sequencing technology and computing have resulted in confounding data regarding pathogenic bacterial profiles in conditions such as PD. Changes in the microbiome with reductions in short-chain fatty acid (SCFA)-producing bacteria and increases in endotoxin-producing bacteria likely contribute to the pathogenesis of PD. GPR109A, a G-protein coupled receptor found on the surface of the intestinal epithelium and immune cells, plays a key role in controlling intestinal permeability and the inflammatory cascade. The absence of GPR109A receptors is associated with decreased concentration of tight junction proteins, leading to increased intestinal permeability and susceptibility to inflammation. In inflammatory states, butyrate acts via GPR109A to increase concentrations of tight junction proteins and improve intestinal permeability. Niacin deficiency is exacerbated in PD by dopaminergic medications. Niacin supplementation has been shown to shift macrophage polarization from pro-inflammatory to an anti-inflammatory profile. Niacin and butyrate, promising nutrients and unique ligands for the G protein-coupled receptor GPR109A, are reviewed in this paper in detail.

    • #21459
      Reuben
      Participant

      It’s always heartening to read these many reports of folks successfully overcoming one or more symptoms of PD with the seeming endless array of “alternative treatments”. I have no reason to doubt any individual’s good fortune. However, it is quite a leap to assume that anyone else’s success is necessarily appropriate or even safe for anyone else. Not intending to be a downer on this, but really, there are so many variables involved that vary from one person to another. For just a few examples, the other, if any, meds that we take; our diet; the brand and/or dosage of the specific recommendation; the duration of the disease; perhaps our age; other medical (and non-medical) conditions present; as well as the interactions of the myriad of possible influencing factors. I guess I’m suggesting being very cautious in generalizing from the experiences of each other. My hope is to find a doctor who is as knowledgeable as a combination of a number of the contributors here (e.g. Russ Hudson on Butyrate and Bolt Upright, and others) and one who is a board certified neurologist with advanced specialization in movement disorders as well as a dedication and commitment and accessibility to their patients. Good luck to me, eh? But one such source who really knows YOU would enhance the feasibility of any treatment recommendations. Of course, I keep reading and appreciate the sharing. At least it raises good questions for a physician you trust. But no doctor or anyone else has all the answers or PD would not be the mystery it continues to be. For every promising lead I read, I find another or two equally credible that dispute it.
      My intent here is not to discourage, but to try to be helpful in the conversation.

      • #21463
        Bolt Upright
        Participant

        Well written Reuben.Everybody is different and to tell you the truth I have spent the last few months looking for one good example of somebody who recovered from PD and have still not found that person.  I have found scientific reports of a couple of people that just seemed to recover on their own, but no names.

        And I want to be clear: I am not a smart man. I did not go to college and have no medical training.

        I have not been diagnosed with PD. I have been diagnosed with REM Sleep Behavior Disorder, which most doctors consider prodromal PD.  I am working, God willing, to avoid that.

        I do feel good about the B3 study from Auburn I linked to above, but take any advice from me with a grain of salt.

        I do think there is hope.  Here is one new exciting development: Caloric vestibular stimulation for the management of motor and non-motor symptoms in Parkinson’s disease
        https://healthunlocked.com/cure-parkinsons/posts/146496859/caloric-vestibular-stimulation-for-the-management-of-motor-and-non-motor-symptoms-in-parkinsons-disease

Viewing 44 reply threads
  • You must be logged in to reply to this topic.

©2021 KLEO Template a premium and multipurpose theme from Seventh Queen

CONTACT US

We're not around right now. But you can send us an email and we'll get back to you, asap.

Sending

Log in with your credentials

or    

Forgot your details?

Create Account