Loneliness raises a person’s risk of developing Parkinson’s disease within 15 years, a long-term study of nearly half a million U.K. residents found, supporting calls into the therapeutic benefits of personally significant social bonds. This work adds to evidence “that loneliness is a substantial psychosocial determinant of health,” the…
Toxic clumps of the protein alpha-synuclein change the way the brain cells most affected by Parkinson’s disease utilize energy, a study shows. Its researchers wanted a clearer understanding of how “key metabolic processes” are affected by the protein’s aggregation, damaging “vulnerable” nerve cells within the brain, they wrote. To…
A neuroscientist at Northwestern University in Chicago was given the 2023 Annemarie Opprecht Parkinson Award, an international honor recognizing significant contributions to Parkinson’s disease research. James Surmeier, PhD, is a professor and chair of university’s neuroscience department, and a scientific advisor to the Michael J. Fox…
Mark Denham, PhD, a scientist in Denmark, has been awarded a patent that covers a new way of using stem cells to create cell therapies for Parkinson’s disease. Securing the patent, which provides two decades of intellectual property protection for the technology, is a first step toward establishing a…
Cognition tests given virtually showed results similar to in-person evaluations for Parkinson’s disease patients with no or mild cognitive impairments, but more work clearly is needed to overcome their technical limitations and improve their reliability, according to a recent study. “In-person cognitive testing with a neuropsychologist remains the gold…
Dosing has begun in a Phase 1 clinical trial that is testing GT-02287, an experimental oral medication being developed to treat Parkinson’s disease caused by mutations in the GBA1 gene. The first two participants in the trial have been dosed, according to the therapy’s developer, Gain Therapeutics. “Initiating first-in-human…
The medical technology company neuro42 will use a $5 million federal grant to help innovate magnetic resonance imaging (MRI) to accommodate emerging technologies and improve outcomes in Parkinson’s disease and other conditions. The grant from the National Institute of Health’s National Institute of Neurological Disorders and Stroke…
Levels of the protein prosaposin, known as PSAP, are altered in the brains of people with Parkinson’s disease, and these changes are linked to worse motor symptoms, a study discovered. Mice lacking PSAP were more susceptible to the loss of nerve cells seen in Parkinson’s patients. Treatment with the…
Adults with Parkinson’s disease are willing to take additional medicine to manage daily off times — when the benefits of standard levodopa therapy wear off — as long as it does not increase the risk of their bodily fluids becoming discolored, according to a patient survey. Survey respondents also…
Vincere Biosciences has been given $700,000 in seed funding by the National Institutes of Health (NIH) to advance in testing USP30 small molecule inhibitors, its candidate therapy aiming to slow or stop progression in Parkinson’s disease. Valid for two years, the Phase I Small Business…
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