News

Low-dose fosgonimeton boosts cognition in dementia patients: Trial

Low-dose fosgonimeton (ATH-1017), an investigational small molecule, may have cognitive benefits for people with Parkinson’s disease-related dementia or dementia with Lewy bodies, according to recent data from a clinical trial. The small exploratory Phase 2 study, called SHAPE (NCT04831281), tested the safety and efficacy of fosgonimeton given once…

NeuroOne’s ablation system cleared by FDA for neurological disorders

The U.S. Food and Drug Administration (FDA) has cleared NeuroOne’s OneRF Ablation System, a brain electrode-guided tool employed in neurosurgical procedures, including those for Parkinson’s disease, to capture electrical activity and selectively destroy nervous tissue within controlled temperature settings. The request was submitted through a 510(k) application, which…

UCLA neurologist aims for greater diversity in clinical trials

A neurologist and movement disorders specialist at the University of California, Los Angeles (UCLA), is working to develop a way to help Parkinson’s disease researchers better assess and recruit Black patients into clinical studies. If successful, the tool planned by Jennifer Adrissi could be adapted for use…

Oral ATH434 improved motor function in monkeys

Alterity Therapeutics‘ ATH434 improved motor performance and overall function in non-human primates with induced Parkinson’s disease, according to data presented at the recent Future of Parkinson’s Disease Conference 2023. The investigational therapy is currently undergoing evaluation in an open-label biomarker study called ATH434-202 (NCT05864365), which has…