Scientists have discovered how to therapeutically target a class of molecular switches called GTPases that are involved in Parkinson’s disease and other conditions but have long been considered undruggable. The findings of this work, led by researchers at the University of California, San Francisco (UCSF), “create a long-awaited opportunity…
News
Rune Labs has launched StrivePD-AI, a new feature in its StrivePD app that uses generative artificial intelligence (GenAI) to create monthly clinical reports based on a continuous stream of observations that show how Parkinson’s disease is progressing in the app’s users over time. The company is cleared…
The American Parkinson Disease Association (APDA) has awarded a total of $2.6 million for the 2024-2025 funding year, to support a range of research projects that aim to advance understanding of Parkinson’s disease. The nationwide grassroots network increased its funding package by more than 30% over last year,…
The U.S. Food and Drug Administration (FDA) has cleared Turing Medical’s automated brain mapping technology designed to help doctors develop personalized plans for deep brain stimulation (DBS) and other neuromodulation therapies in people with neurological conditions such as Parkinson’s disease. Called Bullsai Identify, the platform uses artificial intelligence…
People with a history of damage to the lining of the upper gastrointestinal (GI) tract, called the gastrointestinal mucosa, had an elevated risk of developing Parkinson’s disease in a recent U.S. study. “We found that a history of upper GI mucosal damage was associated with a 76% greater risk…
The first patient with early Parkinson’s disease has been dosed in Ventyx Biosciences‘ Phase 2a clinical trial of Parkinson’s therapy VTX3232, an oral medication designed to reduce inflammation by blocking the activity of the NLRP3 protein. The trial is still recruiting patients at its single site in…
The U.S. Food and Drug Administration (FDA) is encouraging scientists and drug developers to use an alpha-synuclein seed amplification assay (synSAA) to improve the development and efficiency of clinical trials seeking to delay or prevent the development of Parkinson’s and other neurodegenerative diseases that share toxic clumps of that protein…
Regeneron has joined the data syndication program for Koneksa‘s LEARNS study that’s assessing the potential of digital biomarkers for measuring the progression of Parkinson’s disease. The program enables Regeneron to gain immediate and continuous access to data and results as the trial progresses, which may accelerate the…
A newly developed biosensor that can rapidly detect and quantify levels of dopamine — a chemical messenger nerve cells use to communicate — may serve as a low-cost and efficient tool to diagnose and monitor people with Parkinson’s disease or other conditions marked by abnormal dopamine levels. Developed by…
Understanding and identifying epigenetic changes — those that affect gene activity without altering a gene’s DNA sequence — in blood samples from people with Parkinson’s disease and other neurological conditions may help assess the risk of dementia, two independent studies suggest. In one study, changes in DNA methylation, one…
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